Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0HC2E)
Name
Solute carrier SLC47A2 (MATE2)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Solute carrier family 47 member 2; Kidney-specific H(+)/organic cation antiporter; MATE-2; MATE2; Multidrug and toxin extrusion protein 2; hMATE-2
Family Potential-driven transporter (PDT)  >>  Multidrug/oligosaccharidyl-lipid/polysaccharide flippase (MOPF)
Organism
Homo sapiens (Human)
Gene Name SLC47A2 Gene ID
146802
UniProt ID S47A2_HUMAN (click to find more protein-related data of this DBT)
TTD ID T78127 (click to find more therapeutic target data of this DBT)
VARIDT ID DTD0028 (click to find more drug transporter data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCG
HLGKVELASVTLAVAFVNVCGVSVGVGLSSACDTLMSQSFGSPNKKHVGVILQRGALVLL
LCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSV
LNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSML
MICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVF
EAICCVYGGVLRGTGKQAFGAAVNAITYYIIGLPLGILLTFVVRMRIMGLWLGMLACVFL
ATAAFVAYTARLDWKLAAEEAKKHSGRQQQQRAESTATRPGPEKAVLSSVATGSSPGITL
TTYSRSECHVDFFRTPEEAHALSAPTSRLSVKQLVIRRGAALGAASATLMVGLTVRILAT
RH
Function
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Chlorhexidine Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 500 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID S47A2_HUMAN
References
1 Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem. 2013 Feb 14; 56(3):781-795.

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