Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0HX3W) | |||||
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| Name |
Hsp60-Hsp10 complex (HSPD1-HSPE1)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
Heat shock protein 60 complexed with Early-pregnancy factor; Hsp60 complexed with Hsp10; HuCHA60 complexed with Hsp10; 60 kDa chaperonin complexed with 10 kDa chaperonin; 60 kDa heat shock protein, mitochondrial complexed with 10 kDa heat shock protein, mitochondrial; CPN60 complexed with CPN10; Chaperonin 60 complexed with Chaperonin 10; HSP-60 complexed with EPF; Mitochondrial matrix protein P1 complexed with Hsp10; P60 lymphocyte protein complexed with Hsp10
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| Family | Lyase/isomerase/ligase (L/I/G) >> Macromolecular isomerase (EC 5.6) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | CH60_HUMAN | (click to find more protein-related data of this DBT) | |||
| CH10_HUMAN | (click to find more protein-related data of this DBT) | ||||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Ascorbyl palmitate | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Antioxidant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 3100 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| DIG Name: Riboflavin | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Colorant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 > 100000 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| DIG Name: Tannic acid | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Antioxidant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 3800 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| DIG Name: Benzethonium chloride | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Surfactant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 23000 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| DIG Name: Cetrimonium bromide | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Surfactant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 7400 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| DIG Name: Monostearyl citrate | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Emollient
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 4000 nM (estimated based on the structural similarity with CHEMBL78764 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.835820896 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CH60_HUMAN ; CH10_HUMAN | |||||
| References | |||||
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| 1 | HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett. 2019 May 1; 29(9):1106-1112. | ||||
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