Details of the Biological Target of DIG (DBT)
General Information of DBT (ID: ET0KR5D) | |||||
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Name |
Trypsin (PRSS)
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Synonyms |
Click to Show/Hide the Synonyms of This DBT
Cationic trypsinogen; Serine protease; Anionic trypsinogen; Brain trypsinogen; Mesotrypsin; Mesotrypsinogen
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Family | Hydrolase (HDase) >> Peptidase (EC 3.4) | ||||
Organism |
Homo sapiens (Human)
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Gene Name | PRSS1 | Gene ID | |||
UniProt ID | TRY1_HUMAN | (click to find more protein-related data of this DBT) | |||
TTD ID | T27602 | (click to find more therapeutic target data of this DBT) | |||
Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
Sequence |
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK NTIAANS |
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Function |
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
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Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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DIG Name: Oleic acid | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Emulsifying agent; Penetration agent; Solubilizing agent
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 > 200000 nM (tested by experiment) | [1] | ||||
Tested Species | Sus scrofa (Pig) | |||||
UniProt ID | TRYP_PIG | |||||
DIG Name: Linoleic acid | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Emulsifying agent; Penetration agent; Solubilizing agent
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 > 200000 nM (tested by experiment) | [1] | ||||
Tested Species | Sus scrofa (Pig) | |||||
UniProt ID | TRYP_PIG | |||||
References | |||||
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1 | Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex. J Nat Prod. 1998 Nov; 61(11):1352-5. | ||||
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