Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0M0IL)
Name
Gamma-aminobutyric acid receptor (GABRA)
Family Transmembrane channel/porin (TC/P)  >>  Ligand-gated ion channel (LIC)
Organism
Homo sapiens (Human)
UniProt ID GBRA1_HUMAN (click to find more protein-related data of this DBT)
GBRA2_HUMAN (click to find more protein-related data of this DBT)
GBRA3_HUMAN (click to find more protein-related data of this DBT)
GBRA4_HUMAN (click to find more protein-related data of this DBT)
GBRA5_HUMAN (click to find more protein-related data of this DBT)
GBRA6_HUMAN (click to find more protein-related data of this DBT)
TTD ID T64382 (click to find more therapeutic target data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Ethyl isovalerate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 2280 nM (estimated based on the structural similarity with CHEMBL285171 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.756756757
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID GBRA1_RAT ; GBRA2_RAT ; GBRA3_RAT ; GBRA4_RAT ; GBRA5_RAT ; GBRA6_RAT ; GBRB1_RAT ; GBRB2_RAT ; GBRB3_RAT ; GBRD_RAT ; GBRE_RAT ; GBRG1_RAT ; GBRG2_RAT ; GBRG3_RAT ; GBRP_RAT ; Q91ZM7_RAT
          DIG Name: Taurine Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 470 nM (estimated based on the structural similarity with CHEMBL32102 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.903225806
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID GBRA1_RAT ; GBRA2_RAT ; GBRA3_RAT ; GBRA4_RAT ; GBRA5_RAT ; GBRA6_RAT ; GBRB1_RAT ; GBRB2_RAT ; GBRB3_RAT ; GBRD_RAT ; GBRE_RAT ; GBRG1_RAT ; GBRG2_RAT ; GBRG3_RAT ; GBRP_RAT ; Q91ZM7_RAT
          DIG Name: Cinnamaldehyde Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 2280 nM (estimated based on the structural similarity with CHEMBL285171 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.756756757
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID GBRA1_RAT ; GBRA2_RAT ; GBRA3_RAT ; GBRA4_RAT ; GBRA5_RAT ; GBRA6_RAT ; GBRB1_RAT ; GBRB2_RAT ; GBRB3_RAT ; GBRD_RAT ; GBRE_RAT ; GBRG1_RAT ; GBRG2_RAT ; GBRG3_RAT ; GBRP_RAT ; Q91ZM7_RAT
References
1 Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. J Med Chem. 1994 Jan 21; 37(2):275-86.
2 A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid. Bioorg Med Chem Lett. (1996) 6:1709-1714.

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