Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0MZ9O)
Name
Leukemia L1210 cells (L1210)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Mouse leukemia L1210 cells; L 1210; L-1210; Leukemic 1210; Leukemia 1210; Leukemia L1210
Family Cell line (CELL)  >>  Blood cell line (BLOcel)
Organism
Mus musculus (Mouse)
Cellosaurus ID CVCL_0382 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Diisopropanolamine Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent; Emulsifying agent; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 600 nM (estimated based on the structural similarity with CHEMBL77102 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.860465116
                   Tested Species Mus musculus (Mouse)
                   Cellosaurus ID CVCL_0382
          DIG Name: Phenylmercuric acetate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 3000 nM (estimated based on the structural similarity with CHEMBL39469 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.766666667
                   Tested Species Mus musculus (Mouse)
                   Cellosaurus ID CVCL_0382
          DIG Name: Threonine Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 100 ug.mL-1 (estimated based on the structural similarity with CHEMBL319354 ) [3]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Mus musculus (Mouse)
                   Cellosaurus ID CVCL_0382
References
1 Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives. J Med Chem. 2001 Jul 19; 44(15):2451-9.
2 Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage. J Med Chem. 1990 Jun; 33(6):1544-7.
3 Preparation and evaluation of optically active 4,4-difluorothreonine as a potent novel antitumor material. Bioorg Med Chem Lett. (1991) 1:271-276.

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