Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0N9GH) | |||||
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| Name |
Cathepsin B (CTSB)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
APP secretase; APPS; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1
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| Family | Hydrolase (HDase) >> Peptidase (EC 3.4) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | CTSB | Gene ID | |||
| UniProt ID | CATB_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T61746 | (click to find more therapeutic target data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI |
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| Function |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Dibutyl phthalate | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Plasticizing agent; Solvent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 230000 nM (tested by experiment) | [1] | ||||
| Tested Species | Mus musculus (Mouse) | |||||
| UniProt ID | CATB_MOUSE | |||||
| References | |||||
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| 1 | Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):2083-8. | ||||
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