Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0NK3Q)
Name
Amyloid-beta A4 protein (APP)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Amyloid precursor protein; Amyloid-beta A4 protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; Beta-secretase C-terminal fragment; Beta-APP42; Beta-APP40; Alpha-secretase C-terminal fragment; ABPP; APPI; Alzheimer disease amyloid protein; Amyloid intracellular domain 59; Gamma-CTF(59); Amyloid intracellular domain 57; Gamma-CTF(57); Amyloid intracellular domain 50; Gamma-CTF(50)
Family Transmembrane channel/porin (TC/P)  >>  Amyloid beta-protein peptide (ABPP)
Organism
Homo sapiens (Human)
Gene Name APP Gene ID
351
UniProt ID A4_HUMAN (click to find more protein-related data of this DBT)
TTD ID T87024 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Edetic acid Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Complexing agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 7700 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID A4_HUMAN
          DIG Name: Methylene blue Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 500 nM (tested by experiment) [2]
                   Tested Species Homo sapiens (Human)
                   UniProt ID A4_HUMAN
References
1 Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease. J Med Chem. 2013 Sep 12; 56(17):6775-91.
2 Design and synthesis of curcumin derivatives as tau and amyloid dual aggregation inhibitors. Bioorg Med Chem Lett. 2016 Oct 15; 26(20):5024-5028.

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