Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0O6LX) | |||||
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| Name |
Transthyretin (TTR)
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| Synonyms |
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Prealbumin; ATTR; PALB; TBPA
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| Family | Other protein families (OPF) >> Transthyretin (TTR) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | TTR | Gene ID | |||
| UniProt ID | TTHY_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T86462 | (click to find more therapeutic target data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS GPRRYTIAALLSPYSYSTTAVVTNPKE |
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| Function |
Probably transports thyroxine from the bloodstream to the brain. Thyroid hormone-binding protein.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Diethylene glycol monoethyl ether | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Solubilizing agent; Solvent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 10000 nM (estimated based on the structural similarity with CHEMBL155204 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 1 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | TTHY_HUMAN | |||||
| References | |||||
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| 1 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J Med Chem. 2019 Feb 28; 62(4):2076-2082. | ||||
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