Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0PC2B) | |||||
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| Name |
CDK1-CCNB1 complex (CDK1-CCNB1)
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| Synonyms |
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CDK1 complexed with G2/mitotic-specific cyclin-B1; Cell division control protein 2 homolog complexed with G2/mitotic-specific cyclin-B1; Cell division protein kinase 1 complexed with G2/mitotic-specific cyclin-B1; Cyclin-dependent kinase 1 complexed with G2/mitotic-specific cyclin-B1; p34 protein kinase complexed with G2/mitotic-specific cyclin-B1
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| Family | Transmembrane channel/porin (TC/P) >> Nuclear pore complex (NPC) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | CDK1_HUMAN | (click to find more protein-related data of this DBT) | |||
| CCNB1_HUMAN | (click to find more protein-related data of this DBT) | ||||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Raffinose | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Lyophilization aid
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 150 nM (estimated based on the structural similarity with CHEMBL1203920 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 1 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CDK1_HUMAN ; CCNB1_HUMAN | |||||
| References | |||||
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| 1 | Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period. J Med Chem. 2008 Oct 23; 51(20):6421-31. | ||||
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