Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0QX9T) | |||||
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| Name |
Neurofibrillary tangle protein (MAPT)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
Microtubule-associated protein tau; MAPTL; MTBT1; Neurofibrillary tangle protein; PHF-tau; Paired helical filament-tau; Paired helical filamenttau; tau
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| Family | Other protein families (OPF) >> Tubulin (TUB) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | MAPT | Gene ID | |||
| UniProt ID | TAU_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T45593 | (click to find more therapeutic target data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL |
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| Function |
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Methylene blue | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Colorant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | EC50 = 130 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | TAU_HUMAN | |||||
| References | |||||
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| 1 | Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. Eur J Med Chem. 2019 May 1; 169:200-223. | ||||
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