Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0S3II)
Name
Umbilical vein endothelial cells (HUVEC)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human umbilical vein endothelial cells; HUVEC; HUV-EC-C; HUVEC; HUVEC-C
Family Cell line (CELL)  >>  Endothelial cell line (ENDcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_2959 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Methyl cinnamate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 100 ug.mL-1 (estimated based on the structural similarity with CHEMBL1911048 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.972972973
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_2959
          DIG Name: Benzododecinium bromide Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 7500 nM (estimated based on the structural similarity with CHEMBL2414246 ) [2]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_2959
          DIG Name: Solvent orange 2 Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 2830 nM (estimated based on the structural similarity with CHEMBL594474 ) [3]
                   Structural Similarity Tanimoto coefficient = 0.855172414
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_2959
References
1 Novel natural product-based cinnamates and their thio and thiono analogs as potent inhibitors of cell adhesion molecules on human endothelial cells. Eur J Med Chem. 2011 Nov; 46(11):5498-511.
2 Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride. Eur J Med Chem. 2013 Aug; 66:46-55.
3 Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol. Bioorg Med Chem. 2009 Oct 15; 17(20):7344-52.

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