Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0SV8W)
Name
Carcinoma MDA-MB-231 cells (MDA-MB-231)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human breast adenocarcinoma MDA-MB-231 cells; MDA_MB_231; MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA231; MDA231-BRE; MB231; MD Anderson-Metastatic Breast-231
Family Cell line (CELL)  >>  Breast cell line (BREcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0062 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Maltitol Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Binding agent; Coating agent; Diluent; Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 92350 nM (estimated based on the structural similarity with CHEMBL4539030 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.979166667
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0062
          DIG Name: methylparaben Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 20 ug.mL-1 (tested by experiment) [2]
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0062
          DIG Name: Metacresol Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 27000 nM (estimated based on the structural similarity with CHEMBL4470418 ) [3]
                   Structural Similarity Tanimoto coefficient = 0.941860465
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0062
          DIG Name: Stearalkonium chloride Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 3500 nM (estimated based on the structural similarity with CHEMBL2414246 ) [4]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0062
References
1 Novel natural compounds from endophytic fungi with anticancer activity. Eur J Med Chem. 2018 Aug 5; 156:316-343.
2 Bioactive Phenolic Components from the Twigs of Atalantia buxifolia. J Nat Prod. 2018 Jul 27; 81(7):1534-1539.
3 Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales). J Nat Prod. 2018 Dec 28; 81(12):2716-2721.
4 Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride. Eur J Med Chem. 2013 Aug; 66:46-55.

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