Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0T2VX)
Name	Immortalized MDCK cells (MDCK)
Synonyms	Click to Show/Hide the Synonyms of This DBT Dog kidney immortalized MDCK cells; MDCK (NBL-2); NBL-2; Madin-Darby Canine Kidney; Madin Darby Canine Kidney
Family	Cell line (CELL) >> Kidney cell line (KIDcel)
Organism	Canis lupus familiaris (Dog)
Cellosaurus ID	CVCL_0422	(click to find more cell line data of this DBT)

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Monoammonium glycyrrhizate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Emulsifying agent; Flavoring agent
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	EC50 = 15200 nM (estimated based on the structural similarity with CHEMBL441687 )		[1]
Structural Similarity	Tanimoto coefficient = 0.982905983
Tested Species	Canis lupus familiaris (Dog)
Cellosaurus ID	CVCL_0422
DIG Name: Miripirium chloride		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antimicrobial preservative
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 > 350000 nM (estimated based on the structural similarity with CHEMBL593699 )		[2]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Canis lupus familiaris (Dog)
Cellosaurus ID	CVCL_0422

References
1	Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors. Bioorg Med Chem Lett. 2015 Apr 15; 25(8):1742-1746.
2	Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes. Bioorg Med Chem. 2009 Sep 1; 17(17):6329-39.

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