General Information of DBT (ID: ET0VH2M)
Name
Histone deacetylase (HDAC)
Family Hydrolase (HDase)  >>  Carbon-nitrogen hydrolase (EC 3.5)
Organism
Homo sapiens (Human)
UniProt ID HDAC1_HUMAN (click to find more protein-related data of this DBT)
HDAC2_HUMAN (click to find more protein-related data of this DBT)
HDAC3_HUMAN (click to find more protein-related data of this DBT)
HDAC4_HUMAN (click to find more protein-related data of this DBT)
HDAC5_HUMAN (click to find more protein-related data of this DBT)
HDAC6_HUMAN (click to find more protein-related data of this DBT)
HDAC7_HUMAN (click to find more protein-related data of this DBT)
HDAC8_HUMAN (click to find more protein-related data of this DBT)
HDAC9_HUMAN (click to find more protein-related data of this DBT)
TTD ID T65755 (click to find more therapeutic target data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Docusate sodium Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Surfactant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 9600 nM (estimated based on the structural similarity with CHEMBL271677 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.824561404
                   Tested Species Homo sapiens (Human)
                   UniProt ID HDAC1_HUMAN ; HDAC2_HUMAN ; HDAC3_HUMAN ; HDAC4_HUMAN ; HDAC5_HUMAN ; HDAC6_HUMAN ; HDAC7_HUMAN ; HDAC8_HUMAN ; HDAC9_HUMAN
          DIG Name: Ethyl butyrate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 140000 nM (estimated based on the structural similarity with CHEMBL62381 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.807692308
                   Tested Species Homo sapiens (Human)
                   UniProt ID HDAC1_HUMAN ; HDAC2_HUMAN ; HDAC3_HUMAN ; HDAC4_HUMAN ; HDAC5_HUMAN ; HDAC6_HUMAN ; HDAC7_HUMAN ; HDAC8_HUMAN ; HDAC9_HUMAN
References
1 New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1893-7.
2 Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20; 46(24):5097-116.

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