Details of the Biological Target of DIG (DBT)
General Information of DBT (ID: ET0VH2M) | |||||
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Name |
Histone deacetylase (HDAC)
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Family | Hydrolase (HDase) >> Carbon-nitrogen hydrolase (EC 3.5) | ||||
Organism |
Homo sapiens (Human)
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UniProt ID | HDAC1_HUMAN | (click to find more protein-related data of this DBT) | |||
HDAC2_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC3_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC4_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC5_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC6_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC7_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC8_HUMAN | (click to find more protein-related data of this DBT) | ||||
HDAC9_HUMAN | (click to find more protein-related data of this DBT) | ||||
TTD ID | T65755 | (click to find more therapeutic target data of this DBT) | |||
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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DIG Name: Docusate sodium | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Surfactant
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 9600 nM (estimated based on the structural similarity with CHEMBL271677 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.824561404 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HDAC1_HUMAN ; HDAC2_HUMAN ; HDAC3_HUMAN ; HDAC4_HUMAN ; HDAC5_HUMAN ; HDAC6_HUMAN ; HDAC7_HUMAN ; HDAC8_HUMAN ; HDAC9_HUMAN | |||||
DIG Name: Ethyl butyrate | Click to Show/Hide | |||||
Detailed Information | DIG Info click to show the detail info of this DIG | |||||
Functional Class | Click to Show/Hide the Functional Class of This DIG
Flavoring agent
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Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
Biological Activity | IC50 = 140000 nM (estimated based on the structural similarity with CHEMBL62381 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.807692308 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HDAC1_HUMAN ; HDAC2_HUMAN ; HDAC3_HUMAN ; HDAC4_HUMAN ; HDAC5_HUMAN ; HDAC6_HUMAN ; HDAC7_HUMAN ; HDAC8_HUMAN ; HDAC9_HUMAN | |||||
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