Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F12031) | |||||
|---|---|---|---|---|---|
| Name |
Linaclotide 0.072 mg capsule
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| Company |
Allergan
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| Active Pharmaceutical Ingredient (API) | Linaclotide |
API Info
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| Irritable bowel syndrome | ICD-11: DD91 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0N0NF | DIG Info | Calcium chloride | Antimicrobial preservative ... | ||
| E0D8OB | DIG Info | Histidine | Antioxidant ... | ||
| E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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| Potential-driven transporter (PDT) | ||||||
| DBT Name: Integral membrane E16 (SLC7A5) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Histidine | |||||
| Biological Activity | IC50 = 20000 nM (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | LAT1_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 Aug 23; 61(16):7358-7373. | ||||
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