General Information of DFM (ID: F12032)
Name
Linaclotide 0.145 mg capsule
Company
Allergan; Avera McKennan Hospital; Lake Eire Medical & Surgical Supply DBA Quality Care Products
Active Pharmaceutical Ingredient (API) Linaclotide API Info click to show the detail info of this API
Irritable bowel syndrome ICD-11: DD91 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0N0NF DIG Info Calcium chloride Antimicrobial preservative ...
E07QDG DIG Info Leucine Antiadherent ...
E05BSD DIG Info Titanium dioxide Coating agent ...
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Potential-driven transporter (PDT)
            DBT Name: Integral membrane E16 (SLC7A5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Leucine
                    Biological Activity IC50 = 85000 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID LAT1_HUMAN
References
1 Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 Aug 23; 61(16):7358-7373.

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