General Information of DFM (ID: F21389)
Name	Topotecan 0.25 mg capsule
Company	GlaxoSmithKline
Active Pharmaceutical Ingredient (API)	Topotecan		API Info click to show the detail info of this API
	Ovarian cancer		ICD-11: 2C73	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0H2RX	DIG Info	Glyceryl monostearate	Emollient ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 2 (ABCC2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monostearate
Biological Activity	Inhibition ratio = 76 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN
DBT Name: Multidrug resistance protein 1 (ABCB1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monostearate
Biological Activity	Protein expression downregulation = 52.3 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monostearate
Biological Activity	Inhibition ratio = 46 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monostearate
Biological Activity	Inhibition ratio = 47 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Cell line (CELL)
DBT Name: Prostate cancer LNCaP cells (LNCaP)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monostearate
Biological Activity	IC50 > 100000 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0395

References
1	Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-D-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells. J Pharm Pharm Sci. 2008;11(3):45-62.
2	Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers. Mol Pharm. Sep-Oct 2008;5(5):863-75.
3	Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. J Nat Prod. 2002 Feb; 65(2):206-9.

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