General Information of DFM (ID: F23356)
Name	Timolol Maleate eq 0.25% base solution
Company	Valeant Pharms Intl
Active Pharmaceutical Ingredient (API)	Timolol		API Info click to show the detail info of this API
	Essential hypertension		ICD-11: BA00	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0X1KL	DIG Info	Benzalkonium chloride	Antimicrobial preservative ...
	E06YUO	DIG Info	Disodium hydrogenorthophosphate	Buffering agent ...
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Monoamine oxidase (MAO)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	IC50 = 8200 nM (estimated based on the structural similarity with CHEMBL8695 )					[1]
Structural Similarity	Tanimoto coefficient = 0.97260274
Tested Species	Rattus norvegicus (Rat)
UniProt ID	AOFA_RAT ; AOFB_RAT
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	Inhibition ratio = 77.4 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzalkonium chloride
Biological Activity	Ki = 62.1 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN

References
1	Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes. J Med Chem. 1983 Jul; 26(7):1036-42.
2	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.