General Information of DFM (ID: F23411)
Name	Cyclosporine 100mg/ml solution
Company	Novartis
Active Pharmaceutical Ingredient (API)	Cyclosporin A		API Info click to show the detail info of this API
	Rheumatoid arthritis		ICD-11: FA20	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E00PSA	DIG Info	Glyceryl monooleate	Bioadhesive material ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Transferase (TFase)
DBT Name: Diacylglycerol kinase alpha (DGKA)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monooleate
Biological Activity	Ki = 91000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	DGKA_HUMAN
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 2 (ABCC2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monooleate
Biological Activity	Inhibition ratio = 62 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN
DBT Name: Multidrug resistance protein 1 (ABCB1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monooleate
Biological Activity	Protein expression downregulation = 39.1 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monooleate
Biological Activity	Inhibition ratio = 39 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Glyceryl monooleate
Biological Activity	Inhibition ratio = 63 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN

References
1	Identification of a novel DGKalpha inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem. 2019; 164:378-390.
2	Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-D-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells. J Pharm Pharm Sci. 2008;11(3):45-62.
3	Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers. Mol Pharm. Sep-Oct 2008;5(5):863-75.

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