Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E03KJL)
DIG Name	Isoleucine
Synonyms	Click to Show/Hide the Synonyms of This DIG l-isoleucine; Isoleucine; 73-32-5; (2S,3S)-2-Amino-3-methylpentanoic acid; (S)-Isoleucine; H-Ile-OH; (S,S)-Isoleucine; 2S,3S-Isoleucine; L-(+)-Isoleucine; 2-Amino-3-methylvaleric acid; erythro-L-Isoleucine; L-Ile; alpha-Amino-beta-methylvaleric acid; Isoleucine (VAN); 443-79-8; Isoleucinum [Latin]; Isoleucina [Spanish]; Norvaline, 3-methyl-; Valeric acid, 2-amino-3-methyl-; L-Norvaline, 3-methyl-, erythro-; Acetic acid, amino-sec-butyl-; ISOLEUCINE, L-; Pentanoic acid, 2-amino-3-methyl-; CCRIS 5229; iso-leucine; (2S,3S)-alpha-Amino-beta-methyl-n-valeric acid; ile; MFCD00064222; NSC 46708; (2S,3S)-alpha-Amino-beta-merthylvaleric acid; (2S,3S)-alpha-Amino-beta-merthyl-n-valeric acid; 2-Amino-3-methylpentanoic acid, (S-(R,R))-; Acetic acid, amino(1-methylpropyl)-, (R,R)-; L-Isoleucine, 99%; UNII-04Y7590D77; (S-(R,R))-2-Amino-3-methylpentanoic acid; Pentanoic acid, 2-amino-3-methyl-, (S-(R,R))-; (2S,3S)-2-Amino-3-methylpentanoicacid; CHEBI:17191; [S-(R,R)]-2-Amino-3-methylpentanoic acid; 2S-Amino-3S-methylpentanoic acid; DL-Allo-isoleucine; 04Y7590D77; (2S,3S)-alpha-Amino-beta-methylvaleric acid; Isoleucine (L-Isoleucine); Pentanoic acid, 2-amino-3-methyl-, (2S,3S)-; Isoleucina; Isoleucinum; UNII-5HX0BYT4E3; Isoleucine [USAN:INN]; MFCD00004268; H-lle-OH; (2S,3S)-2-amino-3-methylpentanoate; EINECS 200-798-2; 2-amino-3-methylpentanoate; NSC46708; FEMA No. 3295; laevo-isoleucine; 5HX0BYT4E3; L-iso-leucine; HSDB 7798; (L)-Isoleucine; L- iso-Leucine; Isoleucine [USAN:USP:INN:BAN]; Isoleucine (USP); NSC 9958; EINECS 207-139-8; H-Ile; Ile-OH; L-Isoleucine,(S); (+)-L-isoleucine; (+/-)-Isoleucine; L-[14C]Isoleucine; (2S,3S)-a-Amino-b-methylvaleric acid; PubChem12389; PubChem21625; (+/-)-erythro-form; (2S,3S)-a-Amino-b-methyl-n-valeric acid; AI3-18474; L-Isoleucine (JP17); (2S,3S)-2-amino-3-methyl-Pentanoic acid; 2-Amino-3-methylvalerate; Isoleucine, L- (8CI); bmse000041; bmse000866; bmse000884; (+/-)-erythro-Isoleucine; L-Isoleucine (H-lle-OH); SCHEMBL8869; H-Ile-2-Chlorotrityl Resin; sec-C4H9CH(NH2)COOH; Acetic acid, amino-s-butyl-; GTPL3311; CHEMBL1233584; DTXSID1047441; DTXSID2046882; L-Isoleucine: D-allo-isoleucine; BDBM18140; FEMA 3295; Norvaline, 3-methyl-, erythro-; L-Isoleucine, 99%, FCC, FG; Pharmakon1600-01301004; (2S,3S)-a-Amino-b-methylvalerate; HY-N0771; L-Isoleucine, Cell Culture Reagent; ZINC3581355; ANW-36330; LMFA01100047; NSC760109; s3752; SBB037854; L-Isoleucine, Vetec(TM), 98.5%; AKOS015842027; (2S,3S)-a-Amino-b-methyl-n-valerate; AM81842; CCG-266114; CS-W018502; DB00167; MCULE-2215911951; NSC-760109; (2S,3S)-2-amino-3-methyl-Pentanoate; (2S,3S)-alph-Amino-beta-methylvalerate; (2S,3S)-alpha-Amino-beta-methylvalerate; AS-11616; BP-20357; ST079276; (2S,3S)-alpha-Amino-beta-merthylvalerate; 064l222; [S-(R,R)]-2-Amino-3-methylpentanoate; L-Isoleucine, BioUltra, >=99.5% (NT); (2S,3S)-alph-Amino-beta-methylvaleric acid; (2S,3S)-alpha-Amino-beta-methyl-n-valerate; I0181; (2S,3S)-alpha-Amino-beta-merthyl-n-valerate; L-Isoleucine, SAJ special grade, >=99.0%; C00407; D00065; L-Isoleucine, reagent grade, >=98% (HPLC); M03002; Z-4689; 34148-EP2289892A1; 34148-EP2295410A1; 34148-EP2305825A1; 34148-EP2311850A1; L-Isoleucine, Vetec(TM) reagent grade, >=98%; Q484940; Q-201311; (2S,3S)-.alpha.-Amino-.beta.-methyl-n-valeric acid; .alpha.-Amino-.beta.-methylvaleric acid, (2S,3S)-; Pentanoic acid, 2-amino-3-methyl-, [S-(R,R)]-; F8880-9085; Z1250208653; Isoleucine, European Pharmacopoeia (EP) Reference Standard; L-Isoleucine, certified reference material, TraceCERT(R); UNII-0O72R8RF8A component AGPKZVBTJJNPAG-WHFBIAKZSA-N; UNII-5HX0BYT4E3 component AGPKZVBTJJNPAG-WHFBIAKZSA-N; UNII-66PZQ62YA6 component AGPKZVBTJJNPAG-WHFBIAKZSA-N; UNII-N7U7BXP2OI component AGPKZVBTJJNPAG-WHFBIAKZSA-N; E46116A2-987C-4709-9E80-A64DA838D5A1; L-Isoleucine, United States Pharmacopeia (USP) Reference Standard; L-Isoleucine, Pharmaceutical Secondary Standard; Certified Reference Material; (S,S)-2-amino-3-methyl-pentanoicacid;(s,s)-isoleucine;[S-(R,R*)]-2-Amino-3-methylpentanoic acid; 1160211-67-5; L-Isoleucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%; L-Isoleucine, PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture
DIG Function	Antiadherent; Flavoring agent; lubricant
PubChem CID	6306
Formula	C6H13NO2
Canonical SMILES	CC[C@H](C)[C@@H](C(=O)O)N
InChI	1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
InChIKey	AGPKZVBTJJNPAG-WHFBIAKZSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6306"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	131.17	Topological Polar Surface Area	63.3
	XlogP	-1.7	Complexity	103
	Heavy Atom Count	9	Rotatable Bond Count	3
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count	3

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Potential-driven transporter (PDT)
DBT Name: Integral membrane E16 (SLC7A5)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 140000 nM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
UniProt ID	LAT1_HUMAN

References
1	Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 Aug 23; 61(16):7358-7373.

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