Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E08NVW)
DIG Name
Laureth-4
Synonyms    Click to Show/Hide the Synonyms of This DIG
2-(DODECYLOXY)ETHANOL; Ethylene glycol monododecyl ether; 4536-30-5; Laureth 4; Ethanol, 2-(dodecyloxy)-; aetoxisclerol; atossisclerol; ethoxysclerol; Lauryl ethoxylate; 2-dodecoxyethanol; Laureth-1; Aethoxysklerol; Laureth; Thesit; Lauryl monoethoxylate; Lubrol PX; Laureth 9; Lipocol L-1; Cimagel; Lubrol 12A9; Hydroxypolyethoxydodecane; Slovasol S; Rokanol L; Romopal LN; Nikkol BL; Actinol L3; Aldosperse L 9; Ethylene glycol monolauryl ether; Carsonol L 2; Carsonol L 3; Lauryl alcohol oxy ethanol; Simulsol P 4; Alkasurf LAN 1; Alkasurf LAN 3; Chimipal AE 3; Ethoxylated dodecyl alcohol; polyoxyethylenedodecyl ether; Laureth-11; Actinol L 7; Lauromacrogol 400; Noniolite AL 20; Texofor B 9; 40L (polyether); Adeka Carpol M 2; Ethosperse LA 12; Ethosperse LA 23; Mergital LM 11; Polyoxyethylene lauryl ether; Simulsol P 23; Akyporox RLM 22; Akyporox RLM 40; Dodecanol, ethoxylate; BL 9 (polyglycol); Pegnol L 12; Akyporox RLM 160; Akyporox RLM 230; polyoxyethylene 9-lauryl ether; Adekatol LA 1275; Brij 35; Noigen ET 160; Arapol 0712; Newcol 1203; PEG-11 Lauryl ether; Ethoxylated lauryl alcohol; Adeka Carpol MBF 100; nonaethyleneglycol monododecyl ether; UNII-J89TKQ5R54; dodecyl ethyleneglycol monoether; Laureth 4 [USAN]; Laureth 9 [USAN]; Polyoxyethylene dodecyl mono ether; Dodecyl alcohol polyoxyethylene ether; Ethylene glycol mono-n-dodecyl ether; alpha-Dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl); 2-Hydroxyethyl lauryl ether; Glycols, polyethylene, monododecyl ether; Ethylene glycol dodecyl ether; J89TKQ5R54; alpha-Dodecyl-omega-hydroxypoly(oxyethylene); CHEBI:78770; alpha-Dodecyl-omega-hydroxypoly(oxy-1,2-ethanediyl); MFCD00042657; Poly(oxy-1,2-ethanediyl), alpha-dodecyl-omega-hydroxy-; Laureth 4 (USAN); Laureth 9 (USAN); 2-dodecyloxyethan-1-ol; DSSTox_CID_5218; DSSTox_RID_80389; DSSTox_GSID_44676; Brij 30; Lauromacrogol; Thesat; Surfactant WK; Ethanol,2-(dodecyloxy)-; Siponic L; Standamul LA 2; Calgene 40L; LA (Alcohol); CAS-4536-30-5; Du Pont WK; Lipal 4LA; Marlipal 1217; Chemal LA 23; Conion 2P80; PEG-1 Lauryl ether; Brij 30ICI; Brij 30SP; Brij 35L; Brij 36T; Noigen ET 170; Noigen YX 500; Brij 22; Brij 23; Stmer 135; Polyethylene glycol monolauryl ether; Atlas G 2133; Atlas G 3705; Atlas G 3707; Atlas G 4829; Atlas G-2133; Atlas G-3705; EINECS 224-886-5; Conion 275-20; Conion 275-30; Conion 275-80; Dodecan-1-ol, ethoxylated; Conion 275-100; 2-(dodecyloxy)ethan-1-ol; BRN 1748129; Lauromacrogol 400 [INN]; BASE LP 12; Dodecylglycol; AI3-09524; BL 9; CCRIS 3397; LA 7; polyoxyethylene(23)lauryl ether; HSDB 4351; NCI-C54875; Varithena (TN); Asclera (TN); Polidocanol (JAN); Brij35; Laureth- 23; 2-Dodecyloxy-ethanol; Aethoxysklerol (TN); ACMC-1AEVJ; UNII-0AWH8BFG9A; UNII-BD7AST04GA; UNII-MGU0HEW21Q; B 205; 0AWH8BFG9A; BD7AST04GA; MGU0HEW21Q; bmse000753; Brij 30 (TN); Ethoxylated Lauryl Alcohols; UNII-6SU0SC83AH; UNII-WG3R46N0SV; G 3707; 6SU0SC83AH; POLYOXYL LAURYL ETHER; UNII-002FR4N8OV; UNII-APG12V4K45; UNII-ELB3Y6474W; UNII-KZF7XN8153; UNII-N72LMW566G; UNII-QU7U88D04I; UNII-RPD53041LR; WG3R46N0SV; SCHEMBL77030; 4-01-00-02386 (Beilstein Handbook Reference); UNII-OAH19558U1; 002FR4N8OV; APG12V4K45; ELB3Y6474W; KZF7XN8153; N72LMW566G; QU7U88D04I; RPD53041LR; Polyoxyethylene 23 lauryl ether; CHEMBL1201751; DTXSID8044676; UNII-6HQ855798J; UNII-W9D845551A; UNII-Z95S6G8201; CHEBI:31765; DTXSID10891683; Polyoxyethilene(23) lauryl ether; C12E1; OAH19558U1; ZINC8437287; Tox21_113966; Tox21_301593; ANW-30271; SBB060176; STL452914; AKOS024390811; Dodecyl tricosaoxyethylene glycol ether; 6HQ855798J; FP-0044; MCULE-5043607718; W9D845551A; Z95S6G8201; NCGC00256261-01; NCGC00274074-01; A mixture of monolauryl ethers of polyoxyethylene glycols having a statistical average of 8 ethylene oxide groups per molecule; Polyethylene glycol monododecyl ether, the name is followed by a number (400) corresponding approximately to the average molecular mass of the polyethylene glycol portion; E0264; FT-0722559; ST51046408; D01539; D01993; EC 500-002-6; N-; A-Z-N-; A-Fmoc-L-2,4-diaminobutyric acid; Q377036; SR-01000944887; SR-01000944887-1; Ethylene glycol monododecyl ether, BioXtra, >=99.0% (GC); UNII-3Y76363WPB component SFNALCNOMXIBKG-UHFFFAOYSA-N; UNII-P30F471M6B component SFNALCNOMXIBKG-UHFFFAOYSA-N
DIG Function
Dispersing agent; Emulsifying agent; Gelling agent; Penetration agent; Solubilizing agent; Surfactant; Viscosity-controlling agent
PubChem CID
24750
Formula
C14H30O2
Canonical SMILES
CCCCCCCCCCCCOCCO
InChI
1S/C14H30O2/c1-2-3-4-5-6-7-8-9-10-11-13-16-14-12-15/h15H,2-14H2,1H3
InChIKey
SFNALCNOMXIBKG-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=24750"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 230.39 Topological Polar Surface Area 29.5
XlogP 5.1 Complexity 115
Heavy Atom Count 16 Rotatable Bond Count 13
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Primary active transporter (PAT)
            DBT Name: Multidrug resistance protein 1 (ABCB1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio > 230 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
            DBT Name: Urate exporter (BCRP) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio > 50 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID ABCG2_HUMAN
References
1 Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release. 2007 Dec 4;124(1-2):1-5.

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