Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0D6JV)
DIG Name
Lactic acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
lactic acid; 2-hydroxypropanoic acid; DL-Lactic acid; 50-21-5; 2-hydroxypropionic acid; Polylactic acid; Milk acid; lactate; Ethylidenelactic acid; Propanoic acid, 2-hydroxy-; Lactovagan; Tonsillosan; Racemic lactic acid; Ordinary lactic acid; Acidum lacticum; Kyselina mlecna; DL-Milchsaeure; alpha-Hydroxypropionic acid; 1-Hydroxyethanecarboxylic acid; Aethylidenmilchsaeure; 26100-51-6; FEMA No. 2611; Kyselina 2-hydroxypropanova; Propionic acid, 2-hydroxy-; 598-82-3; (RS)-2-Hydroxypropionsaeure; CCRIS 2951; HSDB 800; (+-)-2-Hydroxypropanoic acid; Propanoic acid, hydroxy-; SY-83; alpha-Hydroxypropanoic acid; DL- lactic acid; MFCD00004520; NSC 367919; Sarcolactic acid; AI3-03130; Purac FCC 80; Purac FCC 88; (R)-2-Hydroxy-propionic acid;H-D-Lac-OH; CHEBI:78320; Poly(lactic acid); Lactic acid USP; NSC-367919; NCGC00090972-01; 2-hydroxy-propionic acid; DL-Lactic acid, 90%; Lactic acid (natural); E 270; DSSTox_CID_3192; (+/-)-Lactic acid; C01432; DSSTox_RID_76915; DSSTox_GSID_23192; Milchsaure [German]; Poly(L-lactide); Milchsaure; Polactide; Lacticum acidum; FEMA Number 2611; Kyselina mlecna [Czech]; D(-)-lactic acid; Cheongin samrakhan; UNII-3B8D35Y7S4; CAS-50-21-5; Cheongin Haewoohwan; Cheongin Haejanghwan; Kyselina 2-hydroxypropanova [Czech]; EINECS 200-018-0; EINECS 209-954-4; Lactic acid [USP:JAN]; EPA Pesticide Chemical Code 128929; BRN 5238667; lactasol; Propanoic acid, 2-hydroxy-, homopolymer; 1-Hydroxyethane 1-carboxylic acid; Biolac; 2-Hydroxy-2-methylacetic acid; Lactide Polymer; Chem-Cast; L- Lactic acid; DL-Polylactic acid; Lactate (TN); 3B8D35Y7S4; 2-Hydropropanoic acid; 2-Hydroxypropionicacid; 4b5w; (+,-)-Lactic acid; Lactic acid, tech grade; Propanoic acid, (+-); DL-Lactic Acid, Racemic; HIPURE 88; (.+/-.)-Lactic acid; EC 200-018-0; Lactic acid (7CI,8CI); ACMC-1B0N9; Lactic acid (JP17/USP); Lactic acid, 85%, FCC; Lactic Acid, Racemic, USP; NCIOpen2_000884; L-( pound<<)-Lactic acid; .alpha.-Hydroxypropanoic acid; .alpha.-Hydroxypropionic acid; (RS)-2-hydroxypropanoic acid; Lactic Acid (Fragrance Grade); INS NO.270; L-(+)-Lactic acid, 98%; CC(O)C([O])=O; CHEMBL1200559; DTXSID7023192; Lactic acid, natural, >=85%; (+/-)-2-hydroxypropanoic acid; BDBM23233; HSDB 8244; Lactic Acid, 85 Percent, FCC; DL-Lactic acid, ~90% (T); INS-270; DL-Lactic acid, AR, >=88%; DL-Lactic acid, LR, >=88%; Lactic Acid, 10 Percent Solution; 26811-96-1; Propanoic acid, 2-hydroxy- (9CI); Tox21_111049; Tox21_202455; Tox21_303616; ANW-43668; BBL027466; NSC367919; SBB065762; STL282744; AKOS000118855; AKOS017278364; Tox21_111049_1; AM87208; DB04398; MCULE-5387110670; VC30148; DL-Lactic acid, 85 % (w/w), syrup; Propanoic acid,2-hydroxy-,(.+/-.)-; NCGC00090972-02; NCGC00090972-03; NCGC00257515-01; NCGC00260004-01; 163894-00-6; AK164446; I487; Lactic acid, 1.0N Standardized Solution; Lactic Acid, 85 Percent, Reagent, ACS; DL-Lactic acid 90%, Ph.Eur., synthetic; DB-071134; 235-EP2269610A2; 235-EP2269986A1; 235-EP2269988A2; 235-EP2270000A1; 235-EP2270006A1; 235-EP2270008A1; 235-EP2270014A1; 235-EP2272516A2; 235-EP2272537A2; 235-EP2272817A1; 235-EP2272822A1; 235-EP2272835A1; 235-EP2272844A1; 235-EP2275401A1; 235-EP2275413A1; 235-EP2275421A1; 235-EP2277507A1; 235-EP2277848A1; 235-EP2277858A1; 235-EP2281559A1; 235-EP2281563A1; 235-EP2281819A1; 235-EP2284160A1; 235-EP2284178A2; 235-EP2284179A2; 235-EP2286795A1; 235-EP2287147A2; 235-EP2287153A1; 235-EP2287156A1; 235-EP2287160A1; 235-EP2289510A1; 235-EP2289518A1; 235-EP2289879A1; 235-EP2289883A1; 235-EP2289890A1; 235-EP2292227A2; 235-EP2292231A1; 235-EP2292234A1; 235-EP2292592A1; 235-EP2292611A1; 235-EP2292617A1; 235-EP2292619A1; 235-EP2295416A2; 235-EP2295433A2; 235-EP2295439A1; 235-EP2298734A2; 235-EP2298742A1; 235-EP2298746A1; 235-EP2298747A1; 235-EP2298748A2; 235-EP2298755A1; 235-EP2298757A2; 235-EP2298768A1; 235-EP2301544A1; 235-EP2301919A1; 235-EP2301922A1; 235-EP2301940A1; 235-EP2305248A1; 235-EP2305633A1; 235-EP2305641A1; 235-EP2305646A1; 235-EP2305651A1; 235-EP2305653A1; 235-EP2305655A2; 235-EP2305657A2; 235-EP2305659A1; 235-EP2305662A1; 235-EP2305663A1; 235-EP2305668A1; 235-EP2305672A1; 235-EP2308849A1; 235-EP2308850A1; 235-EP2308854A1; 235-EP2308857A1; 235-EP2308861A1; 235-EP2308869A1; 235-EP2308873A1; 235-EP2308874A1; 235-EP2308875A1; 235-EP2308881A1; 235-EP2308883A1; 235-EP2311801A1; 235-EP2311802A1; 235-EP2311803A1; 235-EP2311807A1; 235-EP2311809A1; 235-EP2311810A1; 235-EP2311811A1; 235-EP2311814A1; 235-EP2311818A1; 235-EP2311821A1; 235-EP2311831A1; 235-EP2311842A2; 235-EP2314575A1; 235-EP2314579A1; 235-EP2314581A1; 235-EP2314583A1; 235-EP2314584A1; 235-EP2314585A1; 235-EP2314586A1; 235-EP2314588A1; 235-EP2316457A1; 235-EP2316458A1; 235-EP2316459A1; 235-EP2316825A1; 235-EP2316826A1; 235-EP2316827A1; 235-EP2316828A1; 235-EP2316836A1; 235-EP2371797A1; 235-EP2371800A1; 235-EP2371814A1; 235-EP2372017A1; 235-EP2374895A1; E-270; FT-0624390; FT-0625477; FT-0627927; FT-0696525; FT-0774042; L0226; Lactic acid solution, ACS reagent, >=85%; Lactic acid solution, USP, 88.0-92.0%; Lactic acid solution, p.a., 84.5-85.5%; Lactic acid, meets USP testing specifications; D00111; PROPANOIC ACID, 2-HYDROXY-, (.+-.)-; DL-Lactic acid, SAJ first grade, 85.0-92.0%; Propanoic acid, 2-hydroxy-, (+-)-, homopolymer; Q161249; DL-Lactic acid, JIS special grade, 85.0-92.0%; Lactic acid solution, Vetec(TM) reagent grade, 85%; F2191-0200; BC10F553-5D5D-4388-BB74-378ED4E24908; Lactic acid, United States Pharmacopeia (USP) Reference Standard; Lactic acid, Pharmaceutical Secondary Standard; Certified Reference Material
DIG Function
Acidulant
PubChem CID
612
Formula
C3H6O3
Canonical SMILES
CC(C(=O)O)O
InChI
1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)
InChIKey
JVTAAEKCZFNVCJ-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=612"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 90.08 Topological Polar Surface Area 57.5
XlogP -0.7 Complexity 59.1
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Haloperidol
 API Info
Schizophrenia [ICD-11: 6A20]
 [1]
       ICD Disease Classification 12 Respiratory system disease Click to Show/Hide
Montelukast
 API Info
Asthma [ICD-11: CA23]
 [2]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Naproxen
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [3]
Tofacitinib
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [4]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Cell line (CELL)
            DBT Name: Fetal lung MRC5 cells (MRC5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 23930 nM (estimated based on the structural similarity with CHEMBL330546 ) [5]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0440
References
1 FDA label for approved haloperidol from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved montelukast from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved naproxen from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved tofacitinib from the official website of the U.S. Food and Drug Administration.
5 Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29; 138:644-660.

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