Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0L7RZ)
DIG Name
Glycine hydrochloride
Synonyms    Click to Show/Hide the Synonyms of This DIG
Glycine hydrochloride; 6000-43-7; 2-aminoacetic acid hydrochloride; GLYCINE, HYDROCHLORIDE; Glycocoll hydrochloride; Aminoacetic acid hydrochloride; glycine-hcl; UNII-225ZLC74HX; 2-aminoacetic acid;hydrochloride; H-Gly-OH.HCl; MFCD00012872; 225ZLC74HX; glycine, chloride; Glycine hydrochloride, 98+%; ST093337; CCRIS 3355; EINECS 227-841-8; Glycine, hydrochloride (1:1); Glycin HCl; ACMC-1B3FG; C2H5NO2.HCl; SCHEMBL37746; Glycine hydrochloride solution; Amino acetic acid hydrochloride; DTXSID7064079; ANW-33409; SBB071447; AKOS015847938; MCULE-4349255299; Glycine hydrochloride, >=99% (HPLC); AS-15481; P524; AB0017062; FT-0622279; G0103; W-105287; Q27253616; F1905-7104; Glycine hydrochloride solution, 100 mM amino acid in 0.1 M HCl, analytical standard; Glycine hydrochloride, PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production., suitable for cell culture
DIG Function
Buffering agent; Disintegrant; Lyophilization aid
PubChem CID
22316
Formula
C2H6ClNO2
Canonical SMILES
C(C(=O)O)N.Cl
InChI
1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
InChIKey
IVLXQGJVBGMLRR-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
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3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 111.53 Topological Polar Surface Area 63.3
XlogP N.A. Complexity 42.9
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Transmembrane channel/porin (TC/P)
            DBT Name: Glutamate receptor NMDA (GRIN) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 68 nM (estimated based on the structural similarity with CHEMBL773 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.964285714
                    Tested Species Rattus norvegicus (Rat)
                    UniProt ID NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT
            DBT Name: Glycine receptor alpha-1 (GLRA1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 = 94000 nM (estimated based on the structural similarity with CHEMBL773 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.964285714
                    Tested Species Homo sapiens (Human)
                    UniProt ID GLRA1_HUMAN
References
1 Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett. 1999 May 17; 9(10):1409-14.
2 Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. J Med Chem. 2007 Sep 20; 50(19):4616-29.

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