Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0NY5F)
DIG Name	Sodium citrate dihydrate
Synonyms	Click to Show/Hide the Synonyms of This DIG Trisodium citrate dihydrate; Sodium citrate dihydrate; 6132-04-3; Sodium citrate tribasic dihydrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate; Citric acid trisodium salt dihydrate; MFCD00150031; Sodium citrate hydrate; trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate; UNII-B22547B95K; B22547B95K; trisodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate; Trisodium citrate dihydrate;Citric acid trisodium salt dihydrate; tri-sodium citrate dihydrate; Citric acid, trisodium salt dihydrate, ACS reagent; sodium 2-hydroxypropane-1,2,3-tricarboxylate dihydrate; Sodiumcitrate; Citric acid, trisodium salt dihydrate, 99%, for biochemistry; Natrum citricum; Tricitrasol (TN); ACMC-20ajao; Sodium citrate (TN); C6H9Na3O9; Sodium citrate [USP:JAN]; DTXSID1049437; Sodium citrate hydrate (JP17); CHEBI:32142; Trisodium citrate dihydrate, ACS; AKOS025293920; Citric acid, trisodium salt, dihydrate; Citronensaeure,Trinatrium-Salz-Dihydrat; Sodium citrate dihydrate, >=99%, FG; BP-31019; R385; Citrate, 0.5M buffer solution, pH 3.0; Citrate, 0.5M buffer solution, pH 4.0; Citrate, 0.5M buffer solution, pH 4.5; Citrate, 0.5M buffer solution, pH 5.0; Citrate, 0.5M buffer solution, pH 5.5; Citrate, 0.5M buffer solution, pH 6.0; Sodium citrate tribasic dihydrate, >=98%; Sodium citrate dihydrate, ACS reagent grade; C13249; D01781; Sodium citrate tribasic dihydrate, AR, >=99%; Sodium citrate tribasic dihydrate, LR, >=99%; Citric acid trisodium salt dihydrate ACS reagent; 124799-EP2287158A1; 124799-EP2295426A1; 124799-EP2295427A1; A835986; Citric acid, trisodium salt dihydrate, 99%, pure; Q22075862; Sodium citrate dihydrate Biochemical grade, Fine Granular; Sodium citrate tribasic dihydrate, USP, 99.0-100.5%; Sodium citrate tribasic dihydrate, ACS reagent, >=99.0%; trisodium 2-oxidanylpropane-1,2,3-tricarboxylate dihydrate; UNII-1Q73Q2JULR component NLJMYIDDQXHKNR-UHFFFAOYSA-K; Sodium citrate tribasic dihydrate, BioUltra, >=99.0% (NT); Sodium citrate tribasic dihydrate, insect cell culture tested; Sodium citrate tribasic dihydrate, JIS special grade, >=99.0%; Sodium citrate tribasic dihydrate, p.a., ACS reagent, 99.0%; Sodium citrate tribasic dihydrate, purum p.a., >=99.0% (NT); Sodium citrate tribasic dihydrate, SAJ first grade, >=99.0%; Sodium citrate tribasic dihydrate, tested according to Ph.Eur.; trisodium 2-hydroxypropane-1,2,3-tricarboxylate--water (1/2); Trisodium citrate dihydrate, meets USP testing specifications; 2-hydroxy-1,2,3-propanetricarboxylic acid trisodium salt dihydrate; Sodium citrate tribasic dihydrate, BioXtra, >=99.0% (titration); Sodium citrate tribasic dihydrate, for molecular biology, >=99%; Sodium citrate tribasic dihydrate, Vetec(TM) reagent grade, 98%; Sodium citrate, United States Pharmacopeia (USP) Reference Standard; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, dihydrate; Sodium citrate tribasic dihydrate, p.a., ACS reagent, reag. ISO, 99-101%; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt, hydrate (1:3:2); Sodium citrate tribasic dihydrate, BioUltra, for molecular biology, >=99.5% (NT); Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, >=99.0% (NT); Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=99.0%; Sodium Citrate, Pharmaceutical Secondary Standard; Certified Reference Material; Sodium citrate tribasic dihydrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%; Sodium citrate tribasic dihydrate, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E331, 99-100.5% (calc. to the dried substance); Sodium citrate tribasic dihydrate, suitable for amino acid analysis, >=98% (titration), powder
DIG Function	Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
PubChem CID	71474
Formula	C6H9Na3O9
Canonical SMILES	C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.O.O.[Na+].[Na+].[Na+]
InChI	1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;21H2/q;3+1;;/p-3
InChIKey	NLJMYIDDQXHKNR-UHFFFAOYSA-K
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=71474"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	294.1	Topological Polar Surface Area	143
	XlogP	N.A.	Complexity	211
	Heavy Atom Count	18	Rotatable Bond Count	2
	Hydrogen Bond Donor Count	3	Hydrogen Bond Acceptor Count	9

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Fluconazole	API Info	Candidiasis [ICD-11: 1F23]		[1]
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[2]
Didanosine	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[3]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[4]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Metformin	API Info	Diabetes mellitus [ICD-11: 5A10]		[5]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Aripiprazole	API Info	Schizophrenia [ICD-11: 6A20]		[6]
Quetiapine	API Info	Schizophrenia [ICD-11: 6A20]		[7]
Buprenorphine	API Info	Opiate dependence [ICD-11: 6C43]		[8]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Levetiracetam	API Info	Focal seizure [ICD-11: 8A68]		[9]
Dopamine	API Info	Parkinsonism [ICD-11: 8A00]		[10]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Phenylephrine	API Info	Juvenile rheumatoid arthritis [ICD-11: FA24]		[11]
Meloxicam	API Info	Rheumatoid arthritis [ICD-11: FA20]		[12]

References
1	FDA label for approved fluconazole from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
4	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
5	FDA label for approved metformin from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved aripiprazole from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved quetiapine from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved buprenorphine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved levetiracetam from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved dopamine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved phenylephrine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved meloxicam from the official website of the U.S. Food and Drug Administration.

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