Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0U2AB)
DIG Name
D&C green no. 6
Synonyms    Click to Show/Hide the Synonyms of This DIG
Solvent green 3; 128-80-3; Quinizarin Green SS; 1,4-Bis(p-tolylamino)anthracene-9,10-dione; C.I. Solvent Green 3; Waxoline Green G; Sudan Green 4B; Quinazarin green; Arlosol Green B; Organol Green J; Cyanine Green G Base; Arlosol Green BS; Amaplast Green OZ; Arlosol Green BSS; Waxoline Green; Macro-lex Green 5B; D & C Green no. 6; Nitro Fast Green GB; Organol Fast Green J; Quinizarine Green Base; C-Green 10; D&C Green 6; Alizarine Green G Base; Green No. 202; 1,4-Bis(p-tolylamino)anthraquinone; Ahcoquinone Cyanine Green Base; 11091 Green; D and C Green No. 6; Toyo Oriental Oil Blue G; 1,4-Di-p-toluidinoanthraquinone; Anthraquinone Green G Base; Alizarine Cyanine Green Base; D&C Green No. 6; Fat Soluble Anthraquinone Green; Fat Soluble Green Anthraquinone; 1,4-Bis(p-toluidino)anthraquinone; 1,4-Bis(p-tolylamine)anthraquinone; Quinizarine Green SS; 1,4-Di-(4'-toluidino)anthraquinone; Alizarine Cyanine Green G Fat Soluble; Fat-soluble Anthraquinone Green; Bis-1,4-p-tolylaminoanthrchinon; 9,10-Anthracenedione, 1,4-bis[(4-methylphenyl)amino]-; C.I. 61565; UNII-4QP5U84YF7; NSC 84207; 1,4-bis(4-methylanilino)anthracene-9,10-dione; Anthraquinone, 1,4-bis(p-tolylamino)-; 1,4-Di(4'-toluidino)anthraquinone; 4QP5U84YF7; MFCD00001195; 9,10-Anthracenedione, 1,4-bis((4-methylphenyl)amino)-; 1,4-bis[(4-methylphenyl)amino]anthracene-9,10-dione; Micro-lex Green 5B; Zelen sudan 4B [Czech]; Zelen sudan 4B; Solvaperm Green GSB; Zelen rozpoustedlova 3 [Czech]; Anthcoquinone Cyanine Green Base; Zelen rozpoustedlova 3; EINECS 204-909-5; BRN 2227927; Bis-1,4-p-tolylaminoanthrchinon [Czech]; C.I. Disperse Green 6:1; CI 61565; 1,4-Bis((4-methylphenyl)amino)-9,10-anthracenedione; HSDB 8006; Anthraquinone, 1,4-di-p-toluidino-; Waxoline Green 6GFW; SOLVENTGREEN3; D&C Green No 6; D&C Green #6; 14-Bis(p-tolylamino)anthracene-910-dione; D C Green No. 6; D.C. Green No. 6; EC 204-909-5; SCHEMBL35556; DTXSID9044376; 1,4-di-4-toluidinoanthraquinone; Anthraquinone,4-bis(p-tolylamino)-; NSC84207; ZINC3861500; ANW-41923; NSC-84207; Solvent Green 3, analytical standard; STK731664; Solvent Green 3, Dye content 95 %; AKOS001712259; MCULE-3441174162; 9, 1,4-bis[(4-methylphenyl)amino]-; Anthraquinone, 1,4-bis(4'-toluidino)-; AK116011; T770; 1,4-Di(4-toluidino)anthra-9,10-quinone; Anthraquinone, 1,4-(4,4'-ditoluidino)-; Anthraquinone, 1,4-di-p-toluidino- (8CI); FT-0606905; Q0021; ST50308436; 1,4-Di(4-toluidino)anthra-9,10-quinone #; WLN: L C666 BV IVJ DMR D1 & GMR D1; J-005628; Q7272243; 1,4-Bis[(4-methylphenyl)amino]anthra-9,10-quinone
DIG Function
Colorant
PubChem CID
31416
Formula
C28H22N2O2
Canonical SMILES
CC1=CC=C(C=C1)NC2=C3C(=C(C=C2)NC4=CC=C(C=C4)C)C(=O)C5=CC=CC=C5C3=O
InChI
1S/C28H22N2O2/c1-17-7-11-19(12-8-17)29-23-15-16-24(30-20-13-9-18(2)10-14-20)26-25(23)27(31)21-5-3-4-6-22(21)28(26)32/h3-16,29-30H,1-2H3
InChIKey
TVRGPOFMYCMNRB-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=31416"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 418.5 Topological Polar Surface Area 58.2
XlogP 7.8 Complexity 619
Heavy Atom Count 32 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Nabumetone
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [1]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Cell line (CELL)
            DBT Name: Prostate cancer PC-3 cells (PC-3) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 3160 nM (estimated based on the structural similarity with CHEMBL1927742 ) [2]
                    Structural Similarity Tanimoto coefficient = 0.901315789
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0035
References
1 FDA label for approved nabumetone from the official website of the U.S. Food and Drug Administration.
2 Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives. Eur J Med Chem. 2012 Jan; 47(1):323-36.

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