General Information of DIG (ID: E0UX1O)
DIG Name	Pluronic P85
DIG Function	Emulsifying agent; Solubilizing agent; Surfactant

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 1 (ABCB1)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 150 % (tested by experiment)				[1]
Tested Species	Homo sapiens (Human)
UniProt ID	MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
DBT Name: Urate exporter (BCRP)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 58 % (tested by experiment)				[2]
Tested Species	Homo sapiens (Human)
UniProt ID	ABCG2_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 70 % (tested by experiment)				[1]
Tested Species	Homo sapiens (Human)
UniProt ID	ABCG2_HUMAN

References
1	Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release. 2007 Dec 4;124(1-2):1-5.
2	Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients. Int J Pharm. 2009 Mar 31;370(1-2):216-9.

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