General Information of DIG (ID: E0V8JC)
DIG Name	Transcutol
DIG Function	Solubilizing agent; Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Primary active transporter (PAT)
DBT Name: Multidrug resistance protein 2 (ABCC2)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio = 50 % (tested by experiment)				[1]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Inhibition ratio > 55 % (tested by experiment)				[2]
Tested Species	Homo sapiens (Human)
UniProt ID	MRP2_HUMAN

References
1	Inhibition of human efflux transporter ABCC2 (MRP2) by self-emulsifying drug delivery system: influences of concentration and combination of excipients. J Pharm Pharm Sci. 2014;17(4):447-60.
2	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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