Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0VY6L)
DIG Name
Laureth-23
Synonyms    Click to Show/Hide the Synonyms of This DIG
Brij-35; Polyethylene glycol monododecyl ether; Polyoxyethylene (23) lauryl ether; 68439-50-9; MFCD00080891; Brij(R) L23; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol; Brij 35 solution; Dehydol LS 2; Brij L23 solution; Brij30; Brij L23; Polyoxyl 23 lauryl ether; Brij?? L23; GENAPOL(R)X-080; Brij, High pure, Brij-30; Brij, High pure, Brij-35; CHEMBL449312; SCHEMBL5314873; Thesit(R), for membrane research; Brij 35, 10% solution in water; 7301AF; C12E23; Brij(R) L23, for molecular biology; AKOS024418763; C58H118O24; MCULE-1164078697; AK172809; Brij(R) L23 solution, ~10% in H2O; Tricosaethylene glycol mono-N-dodecyl ether; Tricosaethylene glycol mono-n-dodecyl ether; ; Brij(R) L23 solution, 30 % (w/v) in H2O; BRIJ 35 POLYOXYETHYLENE (23) LAURYL ETHER; Brij(R) L23, suitable for Stein-Moore chromatography; Decaethylene glycol mono??dodecyl ether, nonionic surfactant; Brij(R) L4, main component: tetraethylene glycol dodecyl ether; Brij(R) L23, main component: tricosaethylene glycol dodecyl ether; Polyoxyl lauryl ether, United States Pharmacopeia (USP) Reference Standard
DIG Function
Dispersing agent; Emulsifying agent; Gelling agent; Penetration agent; Solubilizing agent; Surfactant; Viscosity-controlling agent
PubChem CID
2724258
Formula
C58H118O24
Canonical SMILES
CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
1S/C58H118O24/c1-2-3-4-5-6-7-8-9-10-11-13-60-15-17-62-19-21-64-23-25-66-27-29-68-31-33-70-35-37-72-39-41-74-43-45-76-47-49-78-51-53-80-55-57-82-58-56-81-54-52-79-50-48-77-46-44-75-42-40-73-38-36-71-34-32-69-30-28-67-26-24-65-22-20-63-18-16-61-14-12-59/h59H,2-58H2,1H3
InChIKey
IEQAICDLOKRSRL-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2724258"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 1199.5 Topological Polar Surface Area 233
XlogP 1.8 Complexity 1080
Heavy Atom Count 82 Rotatable Bond Count 79
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 24
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Primary active transporter (PAT)
            DBT Name: Multidrug resistance protein 1 (ABCB1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio = 72 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio = 81.7 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
               Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Inhibition ratio = 89.7 % (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN
References
1 Intestinal transport of bis(12)-hupyridone in Caco-2 cells and its improved permeability by the surfactant Brij-35. Biopharm Drug Dispos. 2011 Apr;32(3):140-50.

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