Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0YA3D)
DIG Name
Succinic acid
Synonyms    Click to Show/Hide the Synonyms of This DIG
succinic acid; butanedioic acid; 110-15-6; Amber acid; Asuccin; Wormwood acid; Dihydrofumaric acid; Katasuccin; Bernsteinsaure; ethylenesuccinic acid; 1,2-Ethanedicarboxylic acid; 1,4-Butanedioic acid; Wormwood; Butandisaeure; Acidum succinicum; Butanedionic acid; Kyselina jantarova; Butane diacid; Ethylene dicarboxylic acid; Spirit of amber; Bernsteinsaure [German]; Kyselina jantarova [Czech]; MFCD00002789; Ammonium succinate; HSDB 791; succinic-acid; UNII-AB6MNQ6J6L; succ; NSC 106449; AI3-06297; Succinic acid, 99%; AB6MNQ6J6L; E363; CHEBI:15741; C4-beta-polymorph; NSC25949; Succinicum acidum; NCGC00159372-02; NCGC00159372-04; Succinellite; ethylenedicarboxylic acid; acide succinique; Sal succini; Acid of amber; DSSTox_CID_3602; WLN: QV2VQ; Succinic acid, ACS reagent; DSSTox_RID_77102; DSSTox_GSID_23602; SIN; Ethylene succinic acid; Ethanedicarboxylic acid; Bernsteinsaeure; sodium succinate (anhydrous); succinate, 9; acide butanedioique; CAS-110-15-6; Succinic acid [NF]; Succinic acid (8CI); Butanedioic acid (9CI); EINECS 203-740-4; BRN 1754069; Dihydrofumarate; Succinicate; Butanedioic acid diammonium salt; Salt of amber; 1cze; Butanedioic acid?; Nat.Succinic Acid; 1,4-Butanedioate; succinic acid group; Succinic acid, 6; Succinic acid, FCC; Succinic Acide,(S); Succinic Acid (SA); Succinic acid, natural; 4lh2; 1,2-Ethanedicarboxylate; Substrate analogue, 11; Succinic acid, ACS grade; bmse000183; bmse000968; CHEMBL576; EC 203-740-4; HOOC-CH2-CH2-COOH; A 12084; 4-02-00-01908 (Beilstein Handbook Reference); ACMC-20995h; GTPL3637; DTXSID6023602; BDBM26121; HMS3885O04; ZINC895030; HY-N0420; STR02803; Tox21_111612; Tox21_201918; Tox21_303247; ANW-16131; BBL002473; LMFA01170043; NSC-25949; NSC106449; s3791; SBB040562; STK387105; Succinic acid, >=99%, FCC, FG; Succinic acid, BioXtra, >=99.0%; AKOS000118899; Tox21_111612_1; CCG-266069; DB00139; LS40373; MCULE-5889111640; NSC-106449; SuccinicAcid(IndustrialGrade&FoodGrade); 4-$l^{1}-oxidanyl-4-oxobutanoic acid; NCGC00159372-03; NCGC00159372-05; NCGC00159372-06; NCGC00257092-01; NCGC00259467-01; Succinic acid, ACS reagent, >=99.0%; AK111253; BP-21128; I847; 98-EP2269610A2; 98-EP2269983A1; 98-EP2269984A1; 98-EP2269986A1; 98-EP2269988A2; 98-EP2269989A1; 98-EP2269990A1; 98-EP2270002A1; 98-EP2270003A1; 98-EP2270006A1; 98-EP2270008A1; 98-EP2270011A1; 98-EP2270505A1; 98-EP2272516A2; 98-EP2272537A2; 98-EP2272827A1; 98-EP2275401A1; 98-EP2275411A2; 98-EP2275412A1; 98-EP2275413A1; 98-EP2275414A1; 98-EP2277507A1; 98-EP2277848A1; 98-EP2277858A1; 98-EP2277866A1; 98-EP2277867A2; 98-EP2280003A2; 98-EP2280006A1; 98-EP2280010A2; 98-EP2281559A1; 98-EP2281563A1; 98-EP2281819A1; 98-EP2284146A2; 98-EP2284147A2; 98-EP2284149A1; 98-EP2284160A1; 98-EP2284165A1; 98-EP2284169A1; 98-EP2284178A2; 98-EP2284179A2; 98-EP2286795A1; 98-EP2287153A1; 98-EP2287155A1; 98-EP2287156A1; 98-EP2287160A1; 98-EP2287161A1; 98-EP2287162A1; 98-EP2289510A1; 98-EP2289518A1; 98-EP2289876A1; 98-EP2289879A1; 98-EP2289883A1; 98-EP2289890A1; 98-EP2292227A2; 98-EP2292231A1; 98-EP2292234A1; 98-EP2292592A1; 98-EP2292611A1; 98-EP2292617A1; 98-EP2292619A1; 98-EP2295401A2; 98-EP2295402A2; 98-EP2295406A1; 98-EP2295416A2; 98-EP2295424A1; 98-EP2295426A1; 98-EP2295427A1; 98-EP2295433A2; 98-EP2295437A1; 98-EP2298731A1; 98-EP2298734A2; 98-EP2298735A1; 98-EP2298742A1; 98-EP2298746A1; 98-EP2298747A1; 98-EP2298748A2; 98-EP2298757A2; 98-EP2298758A1; 98-EP2298759A1; 98-EP2298768A1; 98-EP2298772A1; 98-EP2298775A1; 98-EP2301544A1; 98-EP2301922A1; 98-EP2301924A1; 98-EP2301931A1; 98-EP2301937A1; 98-EP2301940A1; 98-EP2305219A1; 98-EP2305248A1; 98-EP2305257A1; 98-EP2305633A1; 98-EP2305636A1; 98-EP2305641A1; 98-EP2305646A1; 98-EP2305651A1; 98-EP2305653A1; 98-EP2305655A2; 98-EP2305657A2; 98-EP2305659A1; 98-EP2305663A1; 98-EP2305664A1; 98-EP2305673A1; 98-EP2305675A1; 98-EP2305676A1; 98-EP2305679A1; 98-EP2308839A1; 98-EP2308849A1; 98-EP2308850A1; 98-EP2308851A1; 98-EP2308854A1; 98-EP2308857A1; 98-EP2308861A1; 98-EP2308869A1; 98-EP2308872A1; 98-EP2308873A1; 98-EP2308875A1; 98-EP2311807A1; 98-EP2311808A1; 98-EP2311809A1; 98-EP2311810A1; 98-EP2311811A1; 98-EP2311814A1; 98-EP2311818A1; 98-EP2311829A1; 98-EP2311831A1; 98-EP2311834A1; 98-EP2311837A1; 98-EP2311842A2; 98-EP2314295A1; 98-EP2314574A1; 98-EP2314575A1; 98-EP2314576A1; 98-EP2314581A1; 98-EP2314585A1; 98-EP2314586A1; 98-EP2314588A1; 98-EP2314593A1; 98-EP2316457A1; 98-EP2316458A1; 98-EP2316459A1; 98-EP2316825A1; 98-EP2316826A1; 98-EP2316827A1; 98-EP2316828A1; 98-EP2316829A1; 98-EP2316831A1; 98-EP2316834A1; 98-EP2316835A1; 98-EP2316836A1; 98-EP2371797A1; 98-EP2371798A1; 98-EP2371800A1; 98-EP2371802A1; 98-EP2371804A1; 98-EP2371805A1; 98-EP2372017A1; 98-EP2374454A1; 98-EP2374780A1; 98-EP2374781A1; 98-EP2380874A2; Succinic acid, ReagentPlus(R), >=99.0%; CS-0008946; FT-0652509; FT-0773657; N1941; S0100; ST50213944; Succinic acid, p.a., ACS reagent, 99.0%; Succinic acid, SAJ first grade, >=99.0%; T7308; SUCCINIC ACID HIGH PURITY GRADE 2.5KG; Succinic acid, purum p.a., >=99.0% (T); Succinic acid, SAJ special grade, >=99.5%; 1,4-BUTANEDIOIC ACID (SUCCINIC ACID); A14596; C00042; Succinic acid, Vetec(TM) reagent grade, 98%; 47632-EP2281817A1; 47632-EP2311811A1; AB01332192-02; 196539-EP2270007A1; Q213050; SR-01000944556; J-002386; SR-01000944556-2; Z57127453; F2191-0239; 37E8FFFB-70DA-4399-B724-476BD8715EF0; Succinic acid, certified reference material, TraceCERT(R); Succinic acid, puriss. p.a., ACS reagent, >=99.5% (T); Succinic acid, United States Pharmacopeia (USP) Reference Standard; Succinic acid, matrix substance for MALDI-MS, >=99.5% (T), Ultra pure; Succinic acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.0%; Succinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture; Succinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
DIG Function
Buffering agent
PubChem CID
1110
Formula
C4H6O4
Canonical SMILES
C(CC(=O)O)C(=O)O
InChI
1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
InChIKey
KDYFGRWQOYBRFD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1110"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 118.09 Topological Polar Surface Area 74.6
XlogP -0.6 Complexity 92.6
Heavy Atom Count 8 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Ciprofloxacin
 API Info
Endocarditis [ICD-11: 1B12]
 [1]
       ICD Disease Classification 06 Mental/behavioural/neurodevelopmental disorder Click to Show/Hide
Methylphenidate
 API Info
Attention deficit hyperactivity disorder [ICD-11: 6A05]
 [2]
       ICD Disease Classification 16 Genitourinary system disease Click to Show/Hide
Ibuprofen
 API Info
Dysmenorrhea [ICD-11: GA34]
 [3]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Oxidoreductase (ORase)
            DBT Name: HIF-prolyl hydroxylase 2 (EGLN1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity IC50 = 3000 nM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID EGLN1_HUMAN
References
1 FDA label for approved ciprofloxacin from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved ibuprofen from the official website of the U.S. Food and Drug Administration.
4 Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27; 51(22):7053-6.

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