Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00090)
Name
Calcitriol
Synonyms    Click to Show/Hide the Synonyms of This API
calcitriol; Rocaltrol; Calcijex; 32222-06-3; Topitriol; 1alpha,25-Dihydroxyvitamin D3; Silkis; Soltriol; 1alpha,25-Dihydroxycholecalciferol; 1,25-DHCC; 1,25-Dihydroxyvitamin D; Calcitriolum; 1,25-DIHYDROXYCHOLECALCIFEROL; Vectical; 1,25-Dihydroxyvitamin D3; 1alpha,25(OH)2D3; Dihydroxyvitamin D3; Ro 21-5535; 1-alpha,25-Dihydroxyvitamin D3; UNII-FXC9231JVH; DN-101; CHEMBL846; (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol; FXC9231JVH; 1,25-(OH)2-D3; 1a,25-Dihydroxycholecalciferol; CHEBI:17823; 1-alpha-25-dihydroxyvitamin D3; MFCD00867079; NCGC00161327-04; Ro-21-5535; DN 101; (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol; (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol; Ro 215535; Toptriol; 1alpha,25-Dihydroxyvitamin D; Decostriol; (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol; (5Z,7E)-(1S,3R)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol; Calcitriolum [INN-Latin]; 1alpha,25-dihydroxyvitamin D3 / 1alpha,25-dihydroxycholecalciferol / calcitriol; Calcitriol (Rocaltrol); 1,25-Dihydroxycholecaliferol; SMR000466393; 1,25 (OH)2 D3; CCRIS 5522; dihydroxy-vitamin D3; HSDB 3482; 1,25-dihydroxy vitamin D3; EINECS 250-963-8; 1,25-(OH)2D3; Asentar; Calcitrol; Panbonis; 1,25 Dihydroxycholecalciferol; 1.alpha.,25-dihydroxycholecalciferol; 1alpha 25-dihydroxycholecalciferol; Calcitriol solution; Rocaltrol (TN); U 49562; Vitamin D3, 1alpha, 25-Dihydroxy-; Calcitriol [USAN:USP:INN:BAN:JAN]; Cholecalciferol, 1-alpha,25-dihydroxy-; PubChem18818; PubChem19327; Spectrum5_002061; 9,10-Seco(5Z,7E)-5,7,10(19)-cholestatriene-1alpha,3beta,25-triol; DSSTox_CID_2722; Synthetic vitamin D analog; 25-dihydroxycholecalciferol; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1alpha,3beta,5Z,7E)-; SCHEMBL3245; DSSTox_RID_76700; 1a,25-Dihydroxyvitamin D3; 1alpha,25(OH)2-D3; DSSTox_GSID_22722; BSPBio_001287; Calcitriol (JAN/USP/INN); MLS000759536; MLS001424122; A,25-Dihydroxyvitamin D3; BML2-E03; GTPL2779; (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol; DTXSID5022722; BCBcMAP01_000160; CHEBI:93988; BCPP000304; HMS1361A09; HMS1791A09; HMS1989A09; HMS2051F06; HMS2089N03; HMS2232D18; HMS3402A09; ACT06832; EX-A4435; 1,25 DIHYDROXY VITAMIN D3; 1a,25-(OH)2D3; Tox21_111988; BDBM50200182; LMST03020258; NSC749776; 1-alpha,-1,25-Dihydroxyvitamin D3; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol; AKOS015961898; ZINC100015048; AC-1859; BCP9000474; CCG-101001; CD-2027; CS-0388; DB00136; NC00251; NSC-749776; Ro-215535; 1,25(OH2)D3; 1alpha,25-Dihydroxyvitamin D3 solution; IDI1_033757; 1,25(OH)2D3 & CD4; NCGC00161327-01; 1.alpha.,25-Dihydroxyvitamin D(sub 3); CPD000466393; HY-10002; CAS-32222-06-3; 1,25D3; C01673; D00129; W-5161; 62019-EP2292592A1; 62019-EP2298772A1; 62019-EP2308828A2; 62019-EP2308839A1; AB00639957-06; AB00639957_07; 1alpha,25-Dihydroxyvitamin D3, >=99% (HPLC); 222C063; Q139195; SR-01000759361; SR-01000946978; 1alpha,25-Dihydroxyvitamin D3, >=97.0% (HPLC); SR-01000759361-4; SR-01000946978-1; 1.Alpha.,25-Dihydroxy-26,27-hexadeuterovitamin D3; BRD-K27316855-001-06-7; BRD-K27316855-001-19-0; (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol; Calcitriol, European Pharmacopoeia (EP) Reference Standard; (1?,3?,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol; (5Z,10-secocholesta-5,7,10(19)-triene-1.alpha.,3.beta.,25-triol; (1S,3R,5Z,7E,14beta,17alpha)-9,10-secocholesta-5,7,10-triene-1,3,25-triol; 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, (1.alpha.,3.beta,.5Z,7E)-; 1000873-74-4
Clinical Status
Approved
Disease Indication Congenital alopecia ICD-11: LC30 [1]
PubChem CID
5280453
Formula
C27H44O3
Canonical SMILES
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](C[C@@H](C3=C)O)O)C
InChI
1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChIKey
GMRQFYUYWCNGIN-NKMMMXOESA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5280453"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 416.6 Topological Polar Surface Area 60.7
XlogP 5.1 Complexity 688
Heavy Atom Count 30 Rotatable Bond Count 6
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Calcitriol 0.0005 mg capsule Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben sodium; Propylparaben sodium; Butylated hydroxytoluene; Fd&c red no. 40; Fd&c yellow no. 6; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin
                   Dosage Form Oral Capsule
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sodium methylparaben DIG Info Estrogen receptor beta (EC50 = 1860 nM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Propylparaben sodium DIG Info Estrogen receptor alpha (EC50 = 38200 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Isopropyl alcohol; Mannitol; Sorbitol; Ammonia; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Medium-chain triglycerides; Gelatin, unspecified; Shellac; Sorbitan; Starch, corn
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c red no. 40; Fd&c yellow no. 6; Mannitol; Sorbitol; Butylated hydroxyanisole; Ferrosoferric oxide; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin; Sorbitan
                   Dosage Form Oral Capsule
                   Company Golden State Medical Supply; Heritage Pharmaceuticals; Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Butylated hydroxytoluene; Fd&c yellow no. 6; Propylparaben; Sorbitol; Butylated hydroxyanisole; Glycerin; Fd&c red no. 3; Coconut oil
                   Dosage Form Oral Capsule
                   Company Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [10]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Isopropyl alcohol; Mannitol; Sorbitol; Ammonia; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Cardinal Health; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Mannitol; Sorbitol; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Medium-chain triglycerides; Gelatin
                   Dosage Form Oral Capsule
                   Company Avera McKennan Hospital; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 6; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Fd&c red no. 3; Medium-chain triglycerides
                   Dosage Form Oral Capsule
                   Company Bryant Ranch Prepack; Strides Shasun
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 6; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Fd&c red no. 3; Coconut oil
                   Dosage Form Oral Capsule
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 6; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Fd&c red no. 3; Coconut oil
                   Dosage Form Oral Capsule
                   Company Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
          Calcitriol 0.00025 mg capsule Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Isopropyl alcohol; Mannitol; Sorbitol; Ammonia; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Medium-chain triglycerides; Gelatin, unspecified; Shellac; Sorbitan; Starch, corn
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c red no. 40; Fd&c yellow no. 6; Mannitol; Sorbitol; Butylated hydroxyanisole; Ferrosoferric oxide; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin; Sorbitan
                   Dosage Form Oral Capsule
                   Company Aphena Pharma Solutions-Tennessee; Golden State Medical Supply; Heritage Pharmaceuticals; Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben sodium; Propylparaben sodium; Butylated hydroxytoluene; Fd&c yellow no. 6; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Water; Medium-chain triglycerides; Gelatin
                   Dosage Form Oral Capsule
                   Company Amneal Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sodium methylparaben DIG Info Estrogen receptor beta (EC50 = 1860 nM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Propylparaben sodium DIG Info Estrogen receptor alpha (EC50 = 38200 nM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Isopropyl alcohol; Mannitol; Sorbitol; Ammonia; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Cardinal Health; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Mannitol; Sorbitol; Butylated hydroxyanisole; Ferric oxide red; Ferric oxide yellow; Glycerin; Propylene glycol; Titanium dioxide; Medium-chain triglycerides; Gelatin
                   Dosage Form Oral Capsule
                   Company Cardinal Health; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [7]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Butylated hydroxytoluene; Fd&c yellow no. 6; Propylparaben; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Coconut oil
                   Dosage Form Oral Capsule
                   Company Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [10]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 6; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Fd&c red no. 3; Medium-chain triglycerides
                   Dosage Form Oral Capsule
                   Company Atlantic Biologicals; Bryant Ranch Prepack; Strides Shasun
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [6]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 5; Fd&c yellow no. 6; Butylated hydroxyanisole; Ferrosoferric oxide; Glycerin; Titanium dioxide; Coconut oil; Gelatin
                   Dosage Form Oral Capsule
                   Company American Health Packaging; Aphena Pharma Solutions-Tennessee; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [2]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Fd&c yellow no. 6; Sorbitol; Butylated hydroxyanisole; Glycerin; Titanium dioxide; Coconut oil
                   Dosage Form Oral Capsule
                   Company Aphena Pharma Solutions-Tennessee; Carilion Materials Management; Dispensing Solution; Sun Pharmaceutical Industries; Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [5]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
References
1 FDA label for approved calcitriol from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15; 17(8):3207-11.
4 Discovery of natural estrogen receptor modulators with structure-based virtual screening. Bioorg Med Chem Lett. 2013 Jun 1; 23(11):3329-33.
5 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
6 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
7 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
8 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
9 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
10 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.