Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0J0LX)
DIG Name	Butylated hydroxytoluene
Synonyms	Click to Show/Hide the Synonyms of This DIG 2,6-Di-tert-butyl-4-methylphenol; Butylated hydroxytoluene; 128-37-0; Butylhydroxytoluene; 2,6-Di-tert-butyl-p-cresol; 2,6-Di-t-butyl-4-methylphenol; Ionol; BHT; DBPC; Dibunol; Stavox; Ionol CP; Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-; Impruvol; Topanol; Dalpac; Deenax; Ionole; Vianol; Antioxidant KB; 3,5-Di-tert-butyl-4-hydroxytoluene; Antioxidant 4K; Sumilizer BHT; Topanol O; Topanol OC; Vanlube PC; Antioxidant DBPC; Sustane BHT; Tenamene 3; Vanlube PCX; Antioxidant 29; Antioxidant 30; Nonox TBC; Tenox BHT; Di-tert-butyl-p-cresol; Chemanox 11; 2,6-ditert-butyl-4-methylphenol; Ionol 1; Agidol; Catalin CAO-3; Advastab 401; Ionol (antioxidant); BUKS; Parabar 441; Paranox 441; 2,6-Di-tert-butyl-4-cresol; Catalin antioxydant 1; Antrancine 8; Butylated hydroxytoluol; Vulkanox KB; Dibutylated hydroxytoluene; Ional; 2,6-Bis(1,1-dimethylethyl)-4-methylphenol; AO 4K; CAO 1; CAO 3; Di-tert-butyl-p-methylphenol; o-Di-tert-butyl-p-methylphenol; 4-Methyl-2,6-tert-butylphenol; 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene; 2,6-Di-tert-butyl-p-methylphenol; AO 29; NCI-C03598; 2,6-DI-T-BUTYL-P-CRESOL; 4-Methyl-2,6-di-tert-butylphenol; Butyl hydroxy toluene; 2,6-Di-terc.butyl-p-kresol; 4-Hydroxy-3,5-di-tert-butyltoluene; MFCD00011644; FEMA No. 2184; P 21; Bht(food grade); 4-Methyl-2,6-di-terc. butylfenol; 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene; Di-tert-butylcresol; UNII-1P9D0Z171K; Butylated hydroxytoluene (bht); Dbpc(technical grade); E321; p-Cresol, 2,6-di-tert-butyl-; 2,6-ditert-butyl-4-methyl-phenol; 2,6-Di-tert-butyl-4-methyl-phenol; CHEMBL146; CHEBI:34247; 1P9D0Z171K; NSC-6347; 2,6-di-tert-butyl-4-methyl phenol; 2,6-bis(tert-butyl)-4-methylphenol; NCGC00091761-03; Kerabit; Tonarol; 2,6-Di-tert-butyl-4-methylphenol, 99%; DSSTox_CID_216; Antioxidant MPJ; Antioxidant 4; Toxolan P; Alkofen BP; Swanox BHT; Tenamen 3; Antox QT; Antioxidant 264; DSSTox_RID_75440; Agidol 1; DSSTox_GSID_20216; Bht (food grade); Antioxidant T 501; Nocrac 200; Caswell No. 291A; Dbpc (technical grade); Annulex BHT; AOX 4K; AOX 4; CAS-128-37-0; Butylohydroksytoluenu; CCRIS 103; Butylohydroksytoluenu [Polish]; Ionol CP-antioxidant; 1,3-Dioxolane, 99.5+%, pure, stabilized; 2,6-Di-tert-butyl-4-methylphenol, 99.8%; Di-tert-butyl-p-cresol (VAN); HSDB 1147; BHT 264; NSC 6347; EINECS 204-881-4; 2,6-Di-terc.butyl-p-kresol [Czech]; EPA Pesticide Chemical Code 022105; Dibutylcresol; 2,6-Di-tert-butyl-4-methylhydroxybenzene; Popol; AI3-19683; 4-Methyl-2,6-di-terc. butylfenol [Czech]; Lowinox BHT; Nipanox BHT; 1,3-Dioxolane, 99.8%, anhydrous, stabilized with 75 ppm BHT, AcroSeal(R); BHT Swanox; BHT, food grade; 4-Methyl-2,6-di-t-butyl-phenol; Butylhydroxytoluenum; Ionol BHT; Ralox BHT; 2, food grade; Butylated hydroxytoluene [BAN:NF]; Dibutyl-para-cresol; butylated-hydroxytoluene; PubChem20842; Spectrum_001790; ACMC-1BUTL; SpecPlus_000768; Methyldi-tert-butylphenol; Spectrum3_001849; Spectrum5_001612; Hydagen DEO (Salt/Mix); EC 204-881-4; 2,6-di-Butyl-para-cresol; 2.6-di-t-butyl-p-cresol; SCHEMBL3950; 2,6-ditert-butyl-p-cresol; p-Cresol,6-di-tert-butyl-; Di-tert-Butylparamethylphenol; BSPBio_003238; KBioSS_002281; 2,6-di-tert.butyl-p-cresol; Di-tert-Butyl-4-methylphenol; MLS000069425; BIDD:ER0031; Butylated hydroxytoluene (NF); DivK1c_006864; SPECTRUM1600716; 2,6-bis-tert-butyl-p-cresol; 2,6-di-tert-butyl-paracresol; BHT (butylated hydroxytoluene); 2,6-di-tert. butyl-p-cresol; 2,6-di-tert.-butyl-p-cresol; INS NO.321; 2,6-di-tert-butyl-para-cresol; 2,6-di-tert-Butyl-methylphenol; 2,6-ditertbutyl-4-methylphenol; DTXSID2020216; 2,6-di-t butyl-4-methylphenol; 2.6-di-t-butyl-4-methylphenol; FEMA 2184; KBio1_001808; KBio2_002280; KBio2_004848; KBio2_007416; KBio3_002738; 2,6-di-tert-butyl-4-methylenol; 2,6-di-tert-butyl-4methylphenol; 2,6-di-tert-butyl4-methylphenol; 2,6-di-tertbutyl-4-methylphenol; 2,6-ditert.butyl-4-methylphenol; Butylated hydroxyl toluene (BHT); INS-321; NSC6347; 2,6-Di(tert-butyl)hydroxytoluene; 2,6-di(t-butyl)-4-methylphenol; 2,6-di-t- butyl-4-methylphenol; 2,6-di-t-butyl 4-methyl phenol; 2,6-di-t-butyl-4-methyl phenol; 2,6-di-t-butyl-4-methyl-phenol; 3,5-di-t-butyl-4-hydroxytoluene; HMS2091E21; HMS2231M22; HMS3369G17; HMS3750M21; Pharmakon1600-01600716; 2,1-dimethylethyl)-4-methylphenol; 2,6-di-tert-butyl 4-methylphenol; 2,6-di-tert-butyl-4 methylphenol; 2,6-di-tert-butyl4-methyl phenol; 2,6-di-tert.butyl-4-methylphenol; 2,6-ditert.-butyl-4-methylphenol; 2.6-di-tert-butyl-4-methylphenol; 4-methyl-2,6-di-tert.butylphenol; 2,6-di-ter-butyl-4-methyl-phenol; 2,6-Di-tert.-Butyl4-methylphenol; 2,6-ditertiarybutyl-4-methylphenol; 2.6-di- t-butyl- 4-methylphenol; AMY40200; HY-Y0172; STR04334; ZINC1481993; 2,6 -di-tert-butyl-4-methylphenol; 2,6-di(tert-butyl)-4-methylphenol; 2,6-Di-tert-butyl-p-cresol, 8CI; 2,6-di-tert.-butyl-4-methylphenol; Tox21_113537; Tox21_201093; Tox21_303408; 2,6-di-tert-butyl-p-cresol (BHT); 2,6-Di-tert-butyl-para-methylphenol; ANW-19063; BDBM50079507; NSC759563; s6202; SBB040854; STL277184; 2,6-di-tert. butyl-4-methyl phenol; 2,6-Di-(tert-butyl)-4-methylphenol; AKOS000269037; Tox21_113537_1; CCG-207937; CM14391; CS-W020053; MCULE-4627478482; NSC-759563; Phenol, 2,6-di-tert-butyl-4-methyl-; NCGC00091761-01; NCGC00091761-02; NCGC00091761-04; NCGC00091761-05; NCGC00091761-06; NCGC00091761-07; NCGC00257275-01; NCGC00258645-01; AC-10553; AK-90086; L133; SMR000059076; 2,6-Di-tert-butyl-4-methylphenol (BHT); SBI-0052890.P002; 2,6-Di-tert-butyl-4-methylphenol, >=99%; Butylated hydroxytoluene, >=99%, FCC, FG; D0228; E-321; FT-0610731; Phenol,6-bis(1,1-dimethylethyl)-4-methyl-; ST50214443; 2,6-bis-(1,1-dimethylethyl)-4-methylphenol; 4-Methyl-2,6- di(1,1-dimethylethyl)phenol; PK04_181024; 2,6-Di-tert-butyl-1-hydroxy-4-methyl benzene; C14693; D02413; M-6087; MLS-0146297.0001; AB00053233_09; Phenol, 3,5-bis(1,1-dimethylethyl)-4-methyl-; 2,6-Bis(1,1-dimethylethyl)-4-methylphenol, 9CI; 2,6-Di-tert-butyl-4-methylphenol, puriss., 99%; AC-907/25014329; Q221945; SR-01000735918; SR-01000735918-2; W-108376; 9FC4DFC8-480D-487C-A74A-2EC9EECE92C4; BENZENE,1,3-DITERT.BUTYL,2-HYDROXY,5-METHYL; BRD-K53153417-001-01-3; BRD-K53153417-001-06-2; 2,6-D[(CH3)3C]2C6H2(CH3)OHi-tert-butyl-p-cresol; F0001-0395; Z955123624; 2,6-DI(TERT-BUTYL-D9)-4-METHYLPHENOL-3,5,O-D3; 2,6-Di-tert-butyl-4-methylphenol, purum, >=99.0% (GC); WLN: 1X1 & 1 & R BQ E1 CX1 & 1 & 1; 2,6-Di-tert-butyl-4-methylphenol, >=99.0% (GC), powder; 2,6-Di-tert-butyl-4-methylphenol, SAJ first grade, >=99.0%; 2,6-Di-tert-butyl-4-methylphenol, tested according to Ph.Eur.; 3,5-Di-tert-4-butylhydroxytoluene (BHT), analytical standard; 2,6-Di-tert-butyl-4-methylphenol 1000 microg/mL in Acetonitrile; Butylhydroxytoluene, European Pharmacopoeia (EP) Reference Standard; 2,6-Di-tert-butyl-4-methylphenol, certified reference material, TraceCERT(R); Butylated Hydroxytoluene, Pharmaceutical Secondary Standard; Certified Reference Material; Butylated hydroxytoluene, United States Pharmacopeia (USP) Reference Standard
DIG Function	Antioxidant
PubChem CID	31404
Formula	C15H24O
Canonical SMILES	CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C
InChI	1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChIKey	NLZUEZXRPGMBCV-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=31404"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	220.35	Topological Polar Surface Area	20.2
	XlogP	5.3	Complexity	207
	Heavy Atom Count	16	Rotatable Bond Count	2
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	1

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Azithromycin	API Info	Congenital syphilis [ICD-11: 1A60]		[1]
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[2]
Ritonavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[3]
Fidaxomicin	API Info	Clostridium difficile infection [ICD-11: 1A04]		[4]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Prednisolone	API Info	Multiple myeloma [ICD-11: 2A83]		[5]
Everolimus	API Info	Renal cell carcinoma [ICD-11: 2C90]		[6]
Exemestane	API Info	Breast cancer [ICD-11: 2C60]		[7]
ICD Disease Classification 04		Immune system disease	Click to Show/Hide
Cetirizine	API Info	Allergy [ICD-11: 4A80]		[8]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Glipizide	API Info	Diabetes mellitus [ICD-11: 5A10]		[9]
Rosuvastatin	API Info	Hypertriglyceridaemia [ICD-11: 5C80]		[10]
Paricalcitol	API Info	Hyperparathyroidism [ICD-11: 5A51]		[11]
Calcifediol	API Info	Vitamin deficiency [ICD-11: 5B55]		[12]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Sertraline	API Info	Major depressive disorder [ICD-11: 6A70]		[13]
Methylphenidate	API Info	Attention deficit hyperactivity disorder [ICD-11: 6A05]		[14]
Escitalopram	API Info	Major depressive disorder [ICD-11: 6A70]		[15]
Paliperidone	API Info	Bipolar disorder [ICD-11: 6A60]		[16]
Desmopressin acetate	API Info	Enuresis [ICD-11: 6C00]		[17]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Morphine	API Info	Anaesthesia [ICD-11: 8E22]		[18]
Oxycodone	API Info	Anaesthesia [ICD-11: 8E22]		[19]
Hydromorphone	API Info	Anaesthesia [ICD-11: 8E22]		[20]
Hydrocodone	API Info	Anaesthesia [ICD-11: 8E22]		[21]
Deutetrabenazine	API Info	Huntington disease [ICD-11: 8A01]		[22]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Aspirin	API Info	Myocardial infarction [ICD-11: BA41]		[23]
Verapamil	API Info	Essential hypertension [ICD-11: BA00]		[24]
Felodipine	API Info	Essential hypertension [ICD-11: BA00]		[25]
Amlodipine	API Info	Angina pectoris [ICD-11: BA40]		[26]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Metoclopramide	API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]		[27]
Tacrolimus	API Info	Ulcerative colitis [ICD-11: DD71]		[28]
ICD Disease Classification 16		Genitourinary system disease	Click to Show/Hide
Oxybutynin	API Info	Overactive bladder [ICD-11: GC50]		[29]
Dutasteride	API Info	Prostatic hyperplasia [ICD-11: GA90]		[30]
ICD Disease Classification 20		Developmental anomaly	Click to Show/Hide
Calcitriol	API Info	Congenital alopecia [ICD-11: LC30]		[31]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase I (CA1)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 245200 nM (tested by experiment)		[32]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH1_HUMAN
DBT Name: Carbonic anhydrase II (CA2)		Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	Ki = 630 nM (tested by experiment)		[32]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN

References
1	FDA label for approved azithromycin from the official website of the U.S. Food and Drug Administration.
2	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
3	FDA label for approved ritonavir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved fidaxomicin from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved prednisolone from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved everolimus from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved exemestane from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved glipizide from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved paricalcitol from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved calcifediol from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved sertraline from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved methylphenidate from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved escitalopram from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved paliperidone from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved desmopressin acetate from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved morphine from the official website of the U.S. Food and Drug Administration.
19	Efficacy of oxycodone in neuropathic pain: a randomized trial in postherpetic neuralgia. Neurology. 1998 Jun;50(6):1837-41.
20	FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved hydrocodone from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved deutetrabenazine from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved aspirin from the official website of the U.S. Food and Drug Administration.
24	FDA label for approved verapamil from the official website of the U.S. Food and Drug Administration.
25	FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
26	FDA label for approved amlodipine from the official website of the U.S. Food and Drug Administration.
27	FDA label for approved metoclopramide from the official website of the U.S. Food and Drug Administration.
28	FDA label for approved tacrolimus from the official website of the U.S. Food and Drug Administration.
29	FDA label for approved oxybutynin from the official website of the U.S. Food and Drug Administration.
30	FDA label for approved dutasteride from the official website of the U.S. Food and Drug Administration.
31	FDA label for approved calcitriol from the official website of the U.S. Food and Drug Administration.
32	Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15; 17(8):3207-11.

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