Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00805)
Name
Acetohydroxamic acid
Synonyms    Click to Show/Hide the Synonyms of This API
acetohydroxamic acid; N-Hydroxyacetamide; 546-88-3; Lithostat; Acetylhydroxamic acid; Methylhydroxamic acid; Acetic acid, oxime; Acetohydroximic acid; N-Acetylhydroxylamine; Acetamide, N-hydroxy-; Acethydroxamsaeure; cetohyroxamic acid; Acetohydroxamate; Acethydroxamsaure; N-Acetyl hydroxyacetamide; Acethydroxamic acid; AHA; Hydroxylamine, N-acetyl-; Acido acetohidroxamico; Acide acetohydroxamique; Acidum acetohydroxamicum; UNII-4RZ82L2GY5; MFCD00009994; n-hydroxy-acetamide; NSC 176136; Acetamide, N-hydroxy- (9CI); 4RZ82L2GY5; CHEBI:27777; NSC-176136; NCGC00094576-01; DSSTox_CID_2546; WLN: QMV1; Acetyl hydroxyamino; DSSTox_RID_76622; DSSTox_GSID_22546; Acetohydroxamic acid, 98+%; Acethydroxamsaeure [German]; Acide acetohydroxamique [French]; Acido acetohidroxamico [Spanish]; Acidum acetohydroxamicum [Latin]; Lithostat (TN); acetohydroxamic-acid; CAS-546-88-3; CCRIS 1730; HSDB 3585; N-hydroxyacetimidic acid; N-hydroxyethanimidic acid; EINECS 208-913-8; AI3-62232; acetohydroxamsaure; Acetohydroxamic acid (USP/INN); Acetic acid; oxime; N-Oxylatoacetamide; acethydroximic acid; Acetohyroxamic acid; Acetyl hydroxyamine; Prestwick_38; N-oxidanylethanamide; acetohydroxarnic acid; zlchem 200; Acetohydroxamic acid [USAN:USP:INN]; methyl hydroximic acid; Spectrum_000020; ACMC-1AWJW; Spectrum2_000109; Spectrum3_000285; Spectrum4_000138; Spectrum5_000812; CH3C(O)NHOH; CHEMBL734; Acetohydroxamic acid, 98%; BSPBio_001790; KBioGR_000556; KBioSS_000360; MLS001076662; DivK1c_000821; SPECTRUM1500103; SPBio_000098; CC(=O)[N]O; CC(=O)N[O]; DTXSID7022546; CHEBI:49029; HMS502J03; KBio1_000821; KBio2_000360; KBio2_002928; KBio2_005496; KBio3_001290; NSC5073; ZLC0003; NINDS_000821; ACETOHYDROXAMIC ACID (AHA); HMS1920A07; HMS2091G07; HMS2231M17; Pharmakon1600-01500103; ACT05768; HY-B1235; NSC-5073; STR08084; ZINC4658603; Tox21_111301; ANW-32160; BDBM50099857; CA0112; CCG-38927; NSC176136; NSC755855; s4602; AKOS000172340; Tox21_111301_1; AB01014; CS-4881; DB00551; EBD2201963; MCULE-2682231025; NSC-755855; IDI1_000821; NCGC00094576-02; NCGC00094576-03; NCGC00094576-05; AK-43984; BP-13320; SMR000499570; SBI-0051270.P003; AB0010594; DB-052632; A0051; AM20100343; FT-0621796; EN300-36948; 46A883; C06808; D00220; M-3701; AB00051907_07; A830321; Q481822; SR-01000763642; SR-01000763642-2; W-105609; Acetohydroxamic acid, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
PubChem CID
1990
Formula
C2H5NO2
Canonical SMILES
CC(=O)NO
InChI
1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
InChIKey
RRUDCFGSUDOHDG-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL 2D MOL
Physicochemical Properties Molecular Weight 75.07 Topological Polar Surface Area 49.3
XlogP -1.6 Complexity 42.9
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Acetohydroxamic Acid 250mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cellulose; Microcrystalline; Silicon Dioxide; Magnesium Stearate; Peppermint Oil
                   Dosage Form Tablet
                   Company Mission Pharmacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Levomenthol DIG Info Transient receptor potential p8 (EC50 = 10100 nM) [1]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound. ACS Med Chem Lett. 2017 May 31; 8(7):715-719.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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