General Information of DFM (ID: F23063)
Name	Acetohydroxamic Acid 250mg tablet
Company	Mission Pharmacal
Active Pharmaceutical Ingredient (API)	Acetohydroxamic acid		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0V2QO	DIG Info	Cellulose microcrystalline	Adsorbent ...
	E0NG2J	DIG Info	Levomenthol	Flavoring agent
	E01UTP	DIG Info	Magnesium stearate	lubricant
	E01UTV	DIG Info	Silicon dioxide	Anticaking agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Silicon dioxide
Biological Activity	Protein expression downregulation (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Transmembrane channel/porin (TC/P)
DBT Name: Wasabi receptor (TRPA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Levomenthol
Biological Activity	EC50 = 96000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	TRPA1_HUMAN
DBT Name: Transient receptor potential p8 (TRPM8)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Levomenthol
Biological Activity	EC50 = 10100 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	TRPM8_HUMAN
DBT Name: Calcium channel alpha-1C (CAC1C)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Levomenthol
Biological Activity	IC50 = 74600 nM (tested by experiment)					[3]
Tested Species	Oryctolagus cuniculus (Rabbit)
UniProt ID	CAC1C_RABIT

References
1	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
2	Identification of a Novel TRPM8 Agonist from Nutmeg: A Promising Cooling Compound. ACS Med Chem Lett. 2017 May 31; 8(7):715-719.
3	IC50 data for the L-type calcium channel extracted from a set of literature articles.

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