Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00916)
Name
Carglumic acid
Synonyms    Click to Show/Hide the Synonyms of This API
Carglumic acid; 1188-38-1; (S)-2-ureidopentanedioic acid; N-Carbamyl-L-glutamic acid; Carbaglu; N-Carbamylglutamate; N-Carbamoyl-L-glutamic acid; Carbamylglutamic acid; Ureidoglutaric acid; Carbamino-L-glutamic acid; (2S)-2-(carbamoylamino)pentanedioic acid; L-N-Carbamoylglutamic acid; N-Carbamyl-L-glutamate; N-Carbamyl-glutamic Acid; UNII-5L0HB4V1EW; 5L0HB4V1EW; N-carbamoyl-L-glutamate; CHEBI:71028; n-carbamoylglutamate; OE-312; OE 312 (LABORATORY CODE DESIGNATION); DSSTox_CID_26706; DSSTox_RID_81839; DSSTox_GSID_46706; carglumic-acid; carbamylglutamate; Carbaglu (TN); CAS-1188-38-1; N-(Aminocarbonyl)-L-glutamic acid(carglumic acid); L-Glutamic acid, N-(aminocarbonyl)-; Carglumic acid [USAN:INN]; acido carglumico; acide carglumique; acidum carglumicum; NCGC00167549-01; SCHEMBL373546; GTPL7458; CHEMBL1201780; DTXSID7046706; Carglumic acid (JAN/USAN/INN); OE312; BCP16753; HY-B0711; ZINC1530283; Tox21_112544; 3185AA; ANW-52965; MFCD00047874; OE 312; s5301; SBB066020; AKOS010384789; N-carbamyl-L-glutamic acid crystalline; Tox21_112544_1; CS-8208; DB06775; MCULE-6817913906; NCGC00274073-01; DS-17934; Glutamic acid, N-carbamoyl-, L- (8CI); AB0071735; (2S)-2-(aminocarbonylamino)pentanedioic acid; C05829; D07130; Q822884; J-507608; Z1551429737; Carglumic Acid, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
PubChem CID
121396
Formula
C6H10N2O5
Canonical SMILES
C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N
InChI
1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
InChIKey
LCQLHJZYVOQKHU-VKHMYHEASA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
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3D MOL 2D MOL
Physicochemical Properties Molecular Weight 190.15 Topological Polar Surface Area 130
XlogP -2.4 Complexity 227
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Carglumic Acid 200mg tablet for suspension Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Croscarmellose Sodium; Hypromellose; Microcrystalline Cellulose; Silica Colloidal Anhydrous; Sodium Lauryl Sulfate; Sodium Stearyl Fumarate
                   Dosage Form Tablet For Suspension
                   Company Recordati Rare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [1]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [2]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [3]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
References
1 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
2 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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