Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01130)
Name
Glutethimide
Synonyms    Click to Show/Hide the Synonyms of This API
glutethimide; Glutethimid; Glutetimid; Doriden; Noxiron; Glutathimid; Glutetimide; Gluthetimide; Sarodormin; Elrodorm; Noxyron; Glimid; Alfimid; Ondasil; Rigenox; Gimid; 77-21-4; 2-Ethyl-2-phenylglutarimide; Doriden-sed; Glutethimidum; Glutetimidu; 2,6-Piperidinedione, 3-ethyl-3-phenyl-; Glutarimide, 2-ethyl-2-phenyl-; 3-Ethyl-3-phenyl-2,6-piperidinedione; 2-Phenyl-2-ethylglutaric acid imide; 3-Ethyl-3-phenyl-2,6-dioxopiperidine; 3-ethyl-3-phenylpiperidine-2,6-dione; 3-Phenyl-3-ethyl-2,6-dioxopiperidine; 3-Ethyl-3-phenyl-2,6-diketopiperidine; 3-Phenyl-3-ethyl-2,6-diketopiperidine; CC 11511; Phenyl-aethyl-glutarsaeureimid; NSC 95239; CHEBI:5439; .alpha.-Ethyl-.alpha.-phenylglutarimide; .alpha.-Phenyl-.alpha.-ethylglutarimide; NCGC00159407-02; NCGC00159407-04; Glutetimida; Dorimide; Glutetimide [DCIT]; Glutetimidu [Polish]; dl-Glutethimide; DSSTox_CID_3102; .alpha.-Phenyl-.alpha.-ethylglutaric acid imide; DSSTox_RID_76876; DSSTox_GSID_23102; Glutethimidum [INN-Latin]; Glutetimida [INN-Spanish]; alpha-Ethyl-alpha-phenylglutarimide; alpha-Phenyl-alpha-ethylglutarimide; CAS-77-21-4; Doriden (TN); Phenyl-aethyl-glutarsaeureimid [German]; HSDB 3088; alpha-Phenyl-alpha-ethylglutaric acid imide; EINECS 201-012-0; Glutethimide (JAN/INN); Glutethamide; Glutethimide [USP:INN:BAN]; AI3-50601; DEA No. 2550; 2, 3-ethyl-3-phenyl-; CHEMBL1102; SCHEMBL113708; WLN: T6VMVTJ D2 DR; GTPL7192; DTXSID1023102; NSC95239; Tox21_111641; NSC-95239; AKOS015897742; Tox21_111641_1; DB01437; NCGC00159407-03; AC-16077; C07489; D00532; 056G091; Doriden; ; ; Noxiron; ; ; 2-Ethyl-2-phenylglutarimide; Q414236; 3-ethyl-6-hydroxy-3-phenyl-2,3,4,5-tetrahydropyridin-2-one; Glutethimide solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
Clinical Status
Approved
PubChem CID
3487
Formula
C13H15NO2
Canonical SMILES
CCC1(CCC(=O)NC1=O)C2=CC=CC=C2
InChI
1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
InChIKey
JMBQKKAJIKAWKF-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3487"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 217.26 Topological Polar Surface Area 46.2
XlogP 1.9 Complexity 294
Heavy Atom Count 16 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Glutethimide 250mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Cellulose Compounds; Colloidal Silicon Dioxide; Starch; Stearic Acid; Talc
                   Dosage Form Tablet
                   Company Novartis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [1]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [2]
References
1 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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