Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01515)
Name
Urofollitropin
Synonyms    Click to Show/Hide the Synonyms of This API
Urofollitropin; 26995-91-5; 97048-13-0; Fertinex; Fertinorm; Metrodin; Orgafol; Urofollitrophin; SCHEMBL19712185; Q4006490; 1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carbox
Clinical Status
Approved
PubChem CID
62819
Formula
C42H65N11O12S2
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O
InChI
1S/C42H65N11O12S2/c1-6-21(4)33-40(63)52-34(22(5)54)41(64)49-28(16-31(44)56)37(60)50-29(19-67-66-18-25(43)35(58)47-27(38(61)51-33)15-23-9-11-24(55)12-10-23)42(65)53-13-7-8-30(53)39(62)48-26(14-20(2)3)36(59)46-17-32(45)57/h9-12,20-22,25-30,33-34,54-55H,6-8,13-19,43H2,1-5H3,(H2,44,56)(H2,45,57)(H,46,59)(H,47,58)(H,48,62)(H,49,64)(H,50,60)(H,51,61)(H,52,63)
InChIKey
ZDRRIRUAESZNIH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=62819"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 980.2 Topological Polar Surface Area 427
XlogP -1.5 Complexity 1790
Heavy Atom Count 67 Rotatable Bond Count 15
Hydrogen Bond Donor Count 12 Hydrogen Bond Acceptor Count 15
Full List of Drug Formulations (DFMs) Containing This API
          Urofollitropin 75 iu/vial injectable Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate; Polysorbate; Sodium Phosphate Dibasic; Heptahydrate; Phosphoric Acid
                   Dosage Form Injectable
                   Company Ferring
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Phosphoric acid DIG Info Carbonic anhydrase IV (Ki = 9800 nM) [1]
Polysorbate 20 DIG Info Cytochrome P450 2E1 (IC50 = 64.1 uM) [2]
References
1 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5763-7.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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