General Information of DFM (ID: F02791)
Name	Bupropion 522 mg tablet
Company	Sanofi-Aventis
Active Pharmaceutical Ingredient (API)	Bupropion		API Info click to show the detail info of this API
	Nicotine dependence		ICD-11: 6C4A	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E07UZH	DIG Info	Dibutyl sebacate	Plasticizing agent
	E0EI2M	DIG Info	Glyceryl dibehenate	Binding agent ...
	E0V3ER	DIG Info	Polyvinyl alcohol	Coating agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Cytochrome P450 2E1 (CYP2E1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyvinyl alcohol
Biological Activity	IC50 = 548.9 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyvinyl alcohol
Biological Activity	EC50 = 354.8 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN

References
1	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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