Details of the Drug Formulation (DFM)
General Information of DFM (ID: F05856) | |||||
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Name |
Didanosine 125 mg capsule
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Company |
Bristol-Myers Squibb Company
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Active Pharmaceutical Ingredient (API) | Didanosine | API Info click to show the detail info of this API | |||
Human immunodeficiency virus infection | ICD-11: 1C60 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0UN4C | DIG Info | Carboxymethylcellulose sodium | Adsorbent ... | ||
E0N6BJ | DIG Info | Diethyl phthalate | Plasticizing agent ... | ||
E0L2PN | DIG Info | Sodium hydroxide | Alkalizing agent | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carboxymethylcellulose sodium | |||||
Biological Activity | EC50 = 12.6 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2C9 (CYP2C9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carboxymethylcellulose sodium | |||||
Biological Activity | EC50 = 113.2 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2C9_HUMAN | |||||
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carboxymethylcellulose sodium | |||||
Biological Activity | EC50 = 373.8 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2CJ_HUMAN | |||||
DBT Name: Cytochrome P450 3A5 (CYP3A5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carboxymethylcellulose sodium | |||||
Biological Activity | EC50 = 83.7 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A5_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Phosphodiesterase 4D (PDE4D) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Diethyl phthalate | |||||
Biological Activity | IC50 = 8.5 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PDE4D_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carboxymethylcellulose sodium | |||||
Biological Activity | IC50 = 224.7 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lung cancer A-549 cells (A-549) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Diethyl phthalate | |||||
Biological Activity | IC50 = 38000 nM (estimated based on the structural similarity with CHEMBL4071043 ) | [3] | ||||
Structural Similarity | Tanimoto coefficient = 0.970588235 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0023 | |||||
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