Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F16821) | |||||
|---|---|---|---|---|---|
| Name |
Famotidine 20 mg tablet
|
||||
| Company |
7-Eleven; American Sales Company; Amerisource Bergen; BJWC; Big Lots Stores; Cardinal Health; Costco Wholesale; DZA Brands; Dolgencorp; Family Dollar; H E B; Harris Teeter; Humana Pharmacy; Kmart Corporation; Kroger Company; L. Perrigo Company; Major Pharmaceuticals; McKesson; Meijer; Publix Super Markets; Rite Aid; Safecor Health; Safeway; Sam's West; Shopko; SuperValu; Target Corporation; Topco Associates; Wakefern Food Corporation; Wal-Mart Stores; Walgreens Company
|
||||
| Active Pharmaceutical Ingredient (API) | Famotidine |
API Info
 click to show the detail info of this API
|
|||
| Peptic ulcer | ICD-11: DA61 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E03SQI | DIG Info | Carmellose sodium | Disintegrant | ||
| E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
| E01UTP | DIG Info | Magnesium stearate | lubricant | ||
| E0V3ER | DIG Info | Polyvinyl alcohol | Coating agent ... | ||
| E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
| E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
|
|||||
| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Magnesium stearate | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Carmellose sodium | |||||
| Biological Activity | Protein expression upregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Silicon dioxide | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| DBT Name: Cytochrome P450 2E1 (CYP2E1) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
|
|||||
| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Polyvinyl alcohol | |||||
| Biological Activity | IC50 = 548.9 uM (tested by experiment) | [2] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP2E1_HUMAN | |||||
| DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
|
|||||
| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Polyvinyl alcohol | |||||
| Biological Activity | EC50 = 354.8 uM (tested by experiment) | [2] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP2D6_HUMAN | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.