Details of the Drug Formulation (DFM)
General Information of DFM (ID: F17042) | |||||
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Name |
Phendimetrazine 35 mg tablet
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Company |
A-S Medication Solutions; Aidarex Pharmaceuticals; H. J. Harkins Company; KVK Tech; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Phendimetrazine | API Info click to show the detail info of this API | |||
Obesity | ICD-11: 5B81 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E08XEK | DIG Info | Hydrazine yellow | Colorant | ||
E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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G-protein coupled receptor (GPCR) | ||||||
DBT Name: Opioid receptor mu (OPRM1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hydrazine yellow | |||||
Biological Activity | IC50 = 16 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | OPRM_HUMAN | |||||
DBT Name: Dopamine D1 receptor (DRD1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hydrazine yellow | |||||
Biological Activity | IC50 = 23 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | DRD1_HUMAN | |||||
Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Silicon dioxide | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Tyrosyl-DNA phosphodiesterase 2 (TDP2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hydrazine yellow | |||||
Biological Activity | IC50 = 3500 nM (estimated based on the structural similarity with CHEMBL3813826 ) | [3] | ||||
Structural Similarity | Tanimoto coefficient = 0.777777778 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | TYDP2_HUMAN | |||||
Transmembrane channel/porin (TC/P) | ||||||
DBT Name: GABA(A) receptor alpha-1 (GABRA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hydrazine yellow | |||||
Biological Activity | IC50 = 13 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | GBRA1_HUMAN | |||||
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