Details of the Drug Formulation (DFM)
General Information of DFM (ID: F19738) | |||||
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Name |
Selegiline 1.25 mg tablet
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Company |
Valeant Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Selegiline | API Info click to show the detail info of this API | |||
Parkinsonism | ICD-11: 8A00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0BI3X | DIG Info | Aspartame | Flavoring agent | ||
E09QIG | DIG Info | Citric acid monohydrate | Acidulant ... | ||
E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
E06WYP | DIG Info | Glycerin | Antimicrobial preservative ... | ||
E0Q6DQ | DIG Info | Mannitol | Diluent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Hydrolase (HDase) | ||||||
DBT Name: Matrix metalloproteinase-1 (MMP1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | IC50 = 20000 nM (estimated based on the structural similarity with CHEMBL62186 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.916666667 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MMP1_HUMAN | |||||
Transmembrane channel/porin (TC/P) | ||||||
DBT Name: Glycine receptor alpha-1 (GLRA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Mannitol | |||||
Biological Activity | EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 ) | [2] | ||||
Structural Similarity | Tanimoto coefficient = 0.804878049 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | GLRA1_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Pregnane X receptor (NR1I2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | Ki = 13 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NR1I2_HUMAN | |||||
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