Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F20869) | |||||
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| Name |
Temozolomide 20 mg capsule
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| Company |
Chemi Pharma
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| Active Pharmaceutical Ingredient (API) | Temozolomide |
API Info
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| Brain cancer | ICD-11: 2A00 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0A1CS | DIG Info | Ammonia | Alkalizing agent | ||
| E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
| E02FBG | DIG Info | Ferrosoferric oxide | Colorant | ||
| E0ND5Z | DIG Info | Potassium hydroxide | Alkalizing agent | ||
| E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| E0H2SC | DIG Info | Water | Solvent | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Propylene glycol | |||||
| Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88. | ||||
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