Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23345)
Name
Haloperidol Decanoate eq 50mg base/ml injectable
Company
Janssen Pharms
Active Pharmaceutical Ingredient (API) Haloperidol API Info click to show the detail info of this API
Schizophrenia ICD-11: 6A20 Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0D6JV DIG Info Lactic acid Acidulant
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Cell line (CELL)
            DBT Name: Fetal lung MRC5 cells (MRC5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Lactic acid
                    Biological Activity IC50 = 23930 nM (estimated based on the structural similarity with CHEMBL330546 ) [1]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    Cellosaurus ID CVCL_0440
References
1 Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29; 138:644-660.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.