General Information of DFM (ID: F23556)
Name	Tamoxifen Citrate eq 20mg base/10ml solution
Company	Mayne Pharma
Active Pharmaceutical Ingredient (API)	Tamoxifen		API Info click to show the detail info of this API
	Breast cancer		ICD-11: 2C60	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E03GSO	DIG Info	Anethole	Flavoring agent
	E0SF4Y	DIG Info	Ethanol	Antimicrobial preservative ...
	E06WYP	DIG Info	Glycerin	Antimicrobial preservative ...
	E0M1JK	DIG Info	Propylene glycol	Antimicrobial preservative ...
	E0G5FT	DIG Info	Sorbitan tristearate	Dispersing agent ...
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Propylene glycol
Biological Activity	Inhibition ratio < 20 % (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Hydrolase (HDase)
DBT Name: Acetylcholinesterase (ACHE)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Anethole
Biological Activity	IC50 = 3630.78 nM (estimated based on the structural similarity with CHEMBL154155 )					[2]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	ACES_HUMAN

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
2	QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. J Med Chem. 1992 Feb 7; 35(3):584-9.

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