Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23614)
Name
Alprostadil 0.01mg/vial injectable
Company
Pfizer
Active Pharmaceutical Ingredient (API) Alprostadil API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0VD9B DIG Info Alfadex Other agent
E0NY1O DIG Info Benzyl alcohol Antimicrobial preservative ...
E0SJ4H DIG Info Beta-D-lactose Diluent ...
E0H0KW DIG Info Hydrochloric acid Acidulant
E0M5SQ DIG Info Sodium citrate anhydrous Alkalizing agent ...
E0L2PN DIG Info Sodium hydroxide Alkalizing agent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Benzyl alcohol
                    Biological Activity IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.848101266
                    Tested Species Homo sapiens (Human)
                    UniProt ID I23O1_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 90000 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
               Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sodium citrate anhydrous
                    Biological Activity Ki = 99 nM (tested by experiment) [3]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
            DBT Name: Carbonic anhydrase V (CA5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Hydrochloric acid
                    Biological Activity Ki = 156 nM (tested by experiment) [4]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH5A_HUMAN ; CAH5B_HUMAN
      Potential-driven transporter (PDT)
            DBT Name: Norepinephrine transporter (NET) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Alfadex
                    Biological Activity Ki = 1260 nM (estimated based on the structural similarity with CHEMBL1629810 ) [5]
                    Structural Similarity Tanimoto coefficient = 0.983606557
                    Tested Species Homo sapiens (Human)
                    UniProt ID SC6A2_HUMAN
References
1 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
2 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5769-73.
3 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
4 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.
5 DrugMatrix in vitro pharmacology data.

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