General Information of DFM (ID: F23621)
Name	Amikacin 590 mg/8.4 ml injectable
Company	Insmed orporated
Active Pharmaceutical Ingredient (API)	Amikacin		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0TT7O	DIG Info	1,2-Distearoyl-sn-glycero-3-phosphocholine	Other agent
	E0S1ZN	DIG Info	Cholesterol	Emollient ...
	E0T4TW	DIG Info	Sodium chloride	Diluent ...
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Sterol 14-alpha demethylase (CYP51A1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	IC50 > 200000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP51A_HUMAN
Transferase (TFase)
DBT Name: DNA polymerase alpha (POLA)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	IC50 > 500000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	DPOLA_HUMAN
DBT Name: DNA polymerase beta (POLB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	IC50 > 500000 nM (tested by experiment)					[2]
Tested Species	Rattus norvegicus (Rat)
UniProt ID	DPOLB_RAT
Lyase/isomerase/ligase (L/I/G)
DBT Name: DNA topoisomerase II (TOP2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	IC50 > 500000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	TOP2A_HUMAN ; TOP2B_HUMAN
Nuclear receptor (NR)
DBT Name: Androgen receptor (AR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	IC50 > 42657.95 nM (tested by experiment)					[3]
Tested Species	Rattus norvegicus (Rat)
UniProt ID	ANDR_RAT
DBT Name: Nuclear receptor ROR-gamma (RORC)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Cholesterol
Biological Activity	EC50 = 20 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	RORG_HUMAN

References
1	Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar; 35(3):493-500.
2	Molecular design of cholesterols as inhibitors of DNA polymerase alpha. J Med Chem. 2004 Sep 23; 47(20):4971-4.
3	Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. J Med Chem. 2005 Sep 8; 48(18):5666-74.
4	Retinoic Acid Receptor-Related Orphan Receptor t (RORt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy. J Med Chem. 2018 Jul 26; 61(14):5794-5804.

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