General Information of DFM (ID: F23646)
Name
Betamethasone 0.05% cream
Company
A-S Medication Solutions
Active Pharmaceutical Ingredient (API) Betamethasone API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E07AGB DIG Info Cetyl alcohol Coating agent ...
E0IS1Z DIG Info Chlorocresol Antimicrobial preservative
E0SM9B DIG Info Phosphoric acid Acidulant ...
E01RHD DIG Info Polyoxyl 20 cetyl ether Emulsifying agent ...
E0L2PN DIG Info Sodium hydroxide Alkalizing agent
E02UFT DIG Info Sodium phosphate monobasic monohydrate Buffering agent ...
E0XV1Z DIG Info Stearyl alcohol Emollient ...
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      G-protein coupled receptor (GPCR)
            DBT Name: Serotonin receptor 2B (5HT2B) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Chlorocresol
                    Biological Activity IC50 = 1856 nM (estimated based on the structural similarity with CHEMBL398440 ) [1]
                    Structural Similarity Tanimoto coefficient = 0.928571429
                    Tested Species Homo sapiens (Human)
                    UniProt ID 5HT2B_HUMAN
      Oxidoreductase (ORase)
            DBT Name: Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 247.1 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2E1_HUMAN
            DBT Name: Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 391.4 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
            DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity IC50 = 242.8 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2D6_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Phosphoric acid
                    Biological Activity Ki = 9800 nM (estimated based on the structural similarity with CHEMBL1060 ) [3]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
            DBT Name: Cholesterol 25-hydroxylase (CYP1A2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 211.5 uM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP1A2_HUMAN
      Cell line (CELL)
            DBT Name: Breast cancer FM3A cells (FM3A) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Cetyl alcohol
                    Biological Activity EC50 = 1600 nM (estimated based on the structural similarity with CHEMBL28459 ) [4]
                    Structural Similarity Tanimoto coefficient = 0.861111111
                    Tested Species Mus musculus (Mouse)
                    Cellosaurus ID CVCL_3869
References
1 DrugMatrix in vitro pharmacology data.
2 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5763-7.
4 Synthesis and notable antimalarial activity of acyclic peroxides, L-(alkyldioxy)-L-(methyldioxy)cyclododecanes. J Med Chem. 2002 Mar 14; 45(6):1374-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.