General Information of DFM (ID: F23659)
Name	Calcipotriene 0.005% ointment
Company	Northstar Rx
Active Pharmaceutical Ingredient (API)	Calcipotriene		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0NY1O	DIG Info	Benzyl alcohol	Antimicrobial preservative ...
	E06DEM	DIG Info	Cetostearyl alcohol	Emollient ...
	E06WYP	DIG Info	Glycerin	Antimicrobial preservative ...
	E0X2OX	DIG Info	Medium-chain triglyceride	Emollient ...
	E01RHD	DIG Info	Polyoxyl 20 cetyl ether	Emulsifying agent ...
	E0LC7X	DIG Info	Trisodium Phosphate	Other agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Benzyl alcohol
Biological Activity	IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 )					[1]
Structural Similarity	Tanimoto coefficient = 0.848101266
Tested Species	Homo sapiens (Human)
UniProt ID	I23O1_HUMAN
DBT Name: Cytochrome P450 2E1 (CYP2E1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyoxyl 20 cetyl ether
Biological Activity	EC50 = 247.1 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyoxyl 20 cetyl ether
Biological Activity	EC50 = 391.4 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyoxyl 20 cetyl ether
Biological Activity	IC50 = 242.8 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Polyoxyl 20 cetyl ether
Biological Activity	EC50 = 211.5 uM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN
Cell line (CELL)
DBT Name: Colon cancer Caco-2 cells (Caco-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Medium-chain triglyceride
Biological Activity	Inhibition ratio > 36 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)

References
1	O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
2	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
3	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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