Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23660)
Name
Calcipotriene 0.005% ointment
Company
Prasco Laboratories
Active Pharmaceutical Ingredient (API) Calcipotriene API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0LT2O DIG Info Alpha-tocopherol Antimicrobial preservative ...
E06DEM DIG Info Cetostearyl alcohol Emollient ...
E09FSQ DIG Info Diazolidinyl urea Antimicrobial preservative
E0G8XK DIG Info Dichlorobenzyl alcohol Antimicrobial preservative
E0FY2S DIG Info Edetate disodium Complexing agent
E06WYP DIG Info Glycerin Antimicrobial preservative ...
E01RHD DIG Info Polyoxyl 20 cetyl ether Emulsifying agent ...
E0LC7X DIG Info Trisodium Phosphate Other agent
E0H2SC DIG Info Water Solvent
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Oxidoreductase (ORase)
            DBT Name: Cytochrome P450 2E1 (CYP2E1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 247.1 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2E1_HUMAN
            DBT Name: Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 391.4 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2C9_HUMAN
            DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity IC50 = 242.8 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP2D6_HUMAN
      Transferase (TFase)
            DBT Name: Glutathione S-transferase P (GSTP1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Alpha-tocopherol
                    Biological Activity IC50 = 500 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID GSTP1_HUMAN
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Cholesterol 25-hydroxylase (CYP1A2) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Polyoxyl 20 cetyl ether
                    Biological Activity EC50 = 211.5 uM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CP1A2_HUMAN
References
1 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2 Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. J Med Chem. 2018 Sep 13; 61(17):7448-7470.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.