General Information of DFM (ID: F23682)
Name	Ciclopirox 8% solution
Company	Valeant International Bermuda
Active Pharmaceutical Ingredient (API)	Ciclopirox		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0T1GY	DIG Info	Ethyl acetate	Flavoring agent ...
	E0N2PK	DIG Info	Isopropyl alcohol	Antimicrobial preservative ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Cathepsin L (CTSL)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Ethyl acetate
Biological Activity	IC50 > 10000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CATL1_HUMAN
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Ethyl acetate
Biological Activity	Promotion ratio = 43 % (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Cell line (CELL)
DBT Name: Lymphoma P388/ADR cells (P388/ADR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Isopropyl alcohol
Biological Activity	IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 )					[3]
Structural Similarity	Tanimoto coefficient = 0.789473684
Tested Species	Mus musculus (Mouse)
Cellosaurus ID	CVCL_IZ75

References
1	Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorg Med Chem. 2015 Nov 1; 23(21):6974-92.
2	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3	Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.

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